题 目：新型不对称氢键催化 报告人：河南大学、河南师范大学 江志勇 教授 时 间：2019年05月21日（周二）下午3:00 地 点：南京大学仙林校区化学楼 G211 邀请人：俞寿云 教授 (yushouyun@nju.edu.cn) 报告人简介： 江智勇教授，博士生导师，河南省特聘教授，入选国家百千万人才工程，国家有突出贡献中青年专家，国务院政府特殊津贴。本硕博毕业于浙江大学化学系，香港浸会大学及新加坡国立大学博士后，2009年入职河南大学天然药物与免疫工程重点实验室，2018年入职河南师范大学化学化工学院，院长。主要从事氢键参与的不对称有机催化及可见光不对称有机催化，以通讯作者身份在Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.发表SCI论文70篇。 报告摘要： Asymmetric H-bonding catalysis as an important tool is always applied to high active substrates. To overcome this bottleneck, we developed novel chiral α-amino acid- and dipeptide-derived Brønsted base and phase-transfer bifunctional/multifunctional organocatalysts as well as a dicyanopyrazine chromophore (DPZ) as a transition metal-free photocatalyst. Based on these achievements, new and highly efficient ionic and photoredox radical-based asymmetric H-bonding catalytic systems have been established, allowing the successful development of many elusive enantioselective reactions, including direct vinylogous reactions, conjugate addition-protonation reactions, reductive coupling reactions, reductive protonation, dehalogenative protonation and reductive deuteration. Meanwhile, we presented a powerful strategy to enable enantioselective substitution of alkyl halides through photoredox asymmetric radical coupling. 近期代表性论文 [1] Nat. Commun. 2019, 10, 1774. [2] J. Am. Chem. Soc. 2019, 141, 5437-5443. [3] J. Am. Chem. Soc. 2018, 140, 6083-6087. [4] Nat. Commun. 2018, 9, 2445. [5] Angew. Chem. Int. Ed. 2017, 56, 13842-13846. 配位化学国家重点实验室 江苏省先进有机材料重点实验室 |