研究生专题报告暨南京大学高济宇有机化学前沿讲座

题　目：Synthetic G-Quadruplexes: Self-Assembled Ionophores and Ion Transporters that Function in Membranes and in Hydrogels
报告人：Prof. Jeffery Davis
            Department of Chemistry and Biochemistry
            University of Maryland, USA
地   点：化学楼三楼报告厅
时   间：2014年10月13日（星期一）上午10:00
联系人： 王乐勇教授 (lywang@nju.edu.cn), 025-83592529

E-mail：jdavis@umd.edu

Abstract：Our goal is to build “self-assembled ionophores” that selectively bind ions and ion pairs. We hope to use these structures to catalyze ion transport in lipid membranes and in hydrogels. We have used non-covalent interactions to synthesize these supramolecular receptors from simple nucleoside analogs. Lipophilic guanosines form hydrogen-bonded structures based on the G4-quartet. These G4-quartets selectively bind cations and certain ion pairs. Our research goals include:
1) learn how to control structure and dynamics of nucleoside self-association and ion binding;
2) design self-assembled ionophores that selectively bind and transport cations across lipid membranes ;
3) build new functional supramolecular hydrogels.

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                                                                            有机化学学科