21. Qi Wang, Beibei Zhang, Yuang Wang, Xinyu Xu, Kaixuan Zuo, Jingwei Luo, Huanhuan Fan*, Zhe Li*, Huijie Pan*, Shuoxing Jiang*. A ROS-Responsive DNA Nanodevice for Targeted Cytosolic siRNA Delivery in Metabolic Dysfunction-Associated Steatohepatitis. J. Am. Chem. Soc. 2026, 148, 26923-26937.
20. Yuxuan Hong, Xinyu Xu, Ying Yang, Haoyu Chen, Wenhao Yu, Weitao Wang, Yuzhu Lin, Kaixuan Zuo, Huanhuan Fan*, Zijian Guo*. Enhancing the Chemo-Immunotherapeutic Effects of Cisplatin by Hyaluronic Acid-Coated Manganese Dioxide Nanoparticles Through Multiple Mechanisms. CCS Chem. 2026, doi.org/10.31635/ccschem.026.202607642
19. Ying Yang, Yu-Xuan Hong, Xiu-Zhi Yang, Weitao Wang, Wenhao Yu, Haoyu Chen, Huanhuan Fan*, Zijian Guo*. Zinc Chelation Induces PANoptosis and Nuclear DNA Damage to Remodel the Immunosuppressive Tumor Microenvironment. Sci. China Chem. 2026, DOI: 10.1007/s11426-026-3725-5.
18. Ying Yang#, Huanhuan Fan# *, Xinyu Xu, Shankun Yao, Wenhao Yu, Zijian Guo*. Zinc ion-induced immuneresponses in antitumor immunotherapy. CCS Chem. 2024, 6, 2210-2229.
17. Ying Yang, Huanhuan Fan*, Zijian Guo*. Modulation of metal homeostasis for cancer therapy. ChemPlusChem 2024, e202300624.
16. Wenhao Yu, Xinyu Xu, Liuyi Liu, Ying Yang, Huanhuan Fan*, Jie P. Li*, Zijian Guo. Metal-based interventions in the immune molecular machinery. Sci. Sin. Chim. 2024, 54, 762-776.
15. Huanhuan Fan*, Yi Lu*. Improving the sensitivity of a Mn(II)-specific DNAzyme for cellular imaging sensor through sequence mutations. Anal. Chem. 2024, 96, 3853-3858.
14. Xinyu Xu, Yuxuan Hong, Huanhuan Fan*, Zijian Guo. Nucleic Acid-Materials-mediated Innate Immune Activation for Cancer Immunotherapy. ChemMedChem 2024, e202400111.
13. Xinyu Xu, Shumeng Li, Wenhao Yu, Shankun Yao, Huanhuan Fan*, Zijian Guo*. Activation of RIG-I/MDA5 signaling and inhibition of CD47-SIRPα checkpoint with a dual siRNA-assembled nanoadjuvant for robust cancer immunotherapy. Angew. Chem. Int. Ed. 2024, 63, e202318544.
12. Xinyu Xu#, Huanhuan Fan# *, Ying Yang, Shankun Yao, Wenhao Yu, Zijian Guo*, Weihong Tan. Virus-like particle-induced cGAS-STING activation and AIM2 inflammasome-mediated pyroptosis for robust cancer immunotherapy. Angew.Chem. Int. Ed. 2023, 62, e202303010.
11. Zhenzhen Chen, Mohan Chen, Ran Liu, Huanhuan Fan*, Jingjing Zhang*. A cocktail therapeutic strategy based on clofarabine-containing aptamer-PROTAC for enhanced cancer therapy. Chem. Commun. 2023, 59, 11560-11563.
10. Huanhuan Fan*, Claire E. McGhee, Ryan J. Lake, Zhenglin Yang, Zijian Guo, Xiao-Bing Zhang*, Yi Lu*. A highly selective Mn(II)-specific DNAzyme and its application in intracellular sensing. JACS Au 2023, 3, 1615-1622.
9. Huanhuan Fan*, Zijian Guo. Tumor microenvironment-responsive manganese-based nanomaterials for cancer treatment. Coordin. Chem. Rev. 2023, 480, 215027.
8. Mengyi Xiong, Zhenglin Yang, Ryan J. Lake, Junjie Li, Shanni Hong, Huanhuan Fan, Xiao-Bing Zhang*, Yi Lu*. DNAzyme-mediated genetically encoded sensors for ratiometric imaging of metal ions in living cells. Angew. Chem. Int.Ed. 2020, 59, 1891-1896.
7. Xingshu Li#, Huanhuan Fan#, Tian Guo, Huarong Bai, Nahyun Kwon, Sungsook Yu, Yejin Cho, Hyunji Kim, Ki Taek Nam*, Juyoung Yoon*, Xiao-Bing Zhang*, Weihong Tan. Sequential protein-responsive nanophotosensitizer complex for enhancing tumor-specific therapy. ACS Nano 2019, 13, 6702-6710.
6. Huanhuan Fan, Huarong Bai, Qin Liu, Hang Xing, Xiao-Bing Zhang*, Weihong Tan. Monitoring telomerase activity in living cells with high sensitivity using cascade amplification reaction-based nanoprobe. Anal. Chem. 2019, 91, 13143-13151.
5. Huanhuan Fan#, Lili Zhang#, Xiaoxiao Hu#, Zilong Zhao, Huarong Bai, Xiaoyi Fu, Guobei Yan, Li-Hui Liang, Xiao-Bing Zhang*, Weihong Tan. An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species. Chem. Commun. 2018, 54, 4310-4313.
4. Huanhuan Fan, Xiaobing Zhang*, Yi Lu*. Recent advances in DNAzyme-based gene silencing. Sci. China Chem. 2017, 60, 591-601.
3. Huanhuan Fan, Guobei Yan, Zilong Zhao, Xiaoxiao Hu, Wenhan Zhang, Hui Liu, Xiaoyi Fu, Ting Fu, Xiao-Bing Zhang*, Weihong Tan*. A smart photosensitizer-manganese dioxide nanosystem for enhanced photodynamic therapy by reducing glutathione levels in cancer cells. Angew. Chem. Int. Ed. 2016, 55, 5477-5482.
2. Huanhuan Fan#, Zilong Zhao#, Guobei Yan, Xiaobing Zhang, Chao Yang, Hongmin Meng, Zhuo Chen, Hui Liu, Weihong Tan*. A smart DNAzyme-MnO2 nanosystem for efficient gene silencing. Angew. Chem. Int. Ed. 2015, 54, 4801-4805.
1. Zilong Zhao#, Huanhuan Fan#, Gaofeng Zhou, Huarong Bai, Hao Liang, Ruowen Wang, Xiaobing Zhang, Weihong Tan*. Activatable fluorescence/MRI bimodal platform for tumor cell imaging via MnO2 nanosheet-aptamer nanoprobe. J. Am.Chem. Soc. 2014, 136, 11220-11223.