报告题目:Self-Assembled Biomaterials
报告人:Prof. Bing Xu
Department of Chemistry, Brandeis University,
Email: bxu@brandeis.eduURL: http://people.brandeis.edu/~bxu/
报告时间:2024年6月18号(星期二下午)15:00
报告地点:仙林校区化学化工学院A216
报告摘要: In this talk, we will discuss the use of self-assembly to generate biomaterials for various applications. Particularly, we will show three examples. The first case focuses on cell spheroid creation by transcytotic intercellular gelation, a study that couples transcytosis and morphological transformation of peptide assemblies for regenerative medicine and tissue engineering. The second example highlights the cryo-EM structures of nanofibers formed through self-assembly of intrinsically disordered peptides (IDPs), particularly aromatic motif-capped phosphorylated short IDPs. The last case centers on the self-assembly of unnatural peptides, which deplete endogenous cholesterol from cell membranes. We intend to demonstrate the power of molecular design in self-assembled biomaterials.
报告嘉宾简介:
After receiving his BS and MS degrees from Nanjing University in 1987 and 1990, respectively, Bing Xu obtained his PhD in 1996 from the University of Pennsylvania. Before starting his independent research at the Hong Kong University of Science and Technology (HKUST) in August 2000, he was an NIH postdoctoral fellow at Harvard University. Dr. Xu was a tenured professor at HKUST until July 2008 before he returned to Boston. Currently, he is a professor in the Department of Chemistry at Brandeis University. He has made pioneering contributions to metallogels, multifunctional magnetic nanoparticles, self-delivery drugs, supramolecular hydrogels, and enzyme-instructed self-assembly for in-situ anticancer nanomedicine. His current research focuses on the applications of enzymatic noncovalent synthesis in materials, biology, and medicine.