代表性成果 10. Xiaoyan Lu, Xiaoning Wang, Hanwen Liao, Baitong Sha, Yan Zhang,* Jinbo Li,* Tandem-Activatable PROTAC Prodrug for Tumor Biomarker-Driven Near-Infrared Opto-Proteolysis, Angew. Chem. Int. Ed. 2025, 64, e202510641. 9. Chen Li, Shuaishuai Sun, Hao Kong, Xiangqian Xie, Gaolin Liang,* Yan Zhang,* Huan Wang,* Jinbo Li,* A Dual-Locked Cyclopeptide-siRNA Conjugate for Tumor-Specific Gene Silencing, RSC Chem. Biol. 2025, 6, 73-80. 8. Chenghong Zhu, Weishan Wang, Yan Wang, Weijie Zhang,* Yan Zhang,* Jinbo Li,* Targeted Extracellular Protein Degradation by Dendronized DNA Chimeras. ACS Chem. Biol. 2024, 19, 654-659. 7. Weishan Wang, Chenghong Zhu, Bin Zhang, Yi Feng, Yan Zhang,* Jinbo Li,* Self-Assembled Nano-PROTAC Enables Near-Infrared Photodynamic Proteolysis for Cancer Therapy. J. Am. Chem. Soc. 2023, 145, 16642-16649. (Highlighted by Cell Press: Lighting the way to tumor destruction. Trends Pharmacol. Sci. 2023, 44, 750-752.) 6. Yan Wang, Jingzi Zhang, Jiafang Deng, Chengzhi Wang, Lei Fang,* Yan Zhang,* Jinbo Li,* Targeted Degradation of DNA/RNA Binding Proteins via Covalent Hydrophobic Tagging. CCS Chem. 2023, 5, 2207-2214. 5. Chenghong Zhu, Weishan Wang, Yan Wang, Yan Zhang,* Jinbo Li,* Dendronized DNA Chimeras Harness Scavenger Receptors To Degrade Cell Membrane Proteins. Angew. Chem. Int. Ed. 2023, 62, e202300694. 4. Xingxing Wang, Xiao Xiao, Yi Feng, Jinbo Li,* Yan Zhang,* A Photoresponsive Antibody-siRNA Conjugate for Activatable Immunogene Therapy of Cancer. Chem. Sci. 2022, 13, 5345-5352. 3. Lei Chen, Gaigai Li, Xingxing Wang, Jinbo Li,* Yan Zhang,* Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of Small-Interfering RNA and Antisense Oligonucleotide. ACS Nano 2021, 15, 11929-11939. 2. Jinbo Li, Hao Kong, Lei Huang, Bo Cheng, Ke Qin, Mengmeng Zheng, Zheng Yan, Yan Zhang,* Visible Light-Initiated Bioorthogonal Photoclick Cycloaddition. J. Am. Chem. Soc. 2018, 140, 14542-14546. 1. Jinbo Li, Lei Huang, Xiao Xiao, Yingjie Chen, Xingxing Wang, Zhengquan Zhou, Chenyu Zhang,* Yan Zhang,* Photoclickable MicroRNA for the Intracellular Target Identification of MicroRNAs. J. Am. Chem. Soc. 2016, 138, 15943-15949. |