1)光学显微成像仪器的研制
2)单分子、单细胞、单颗粒
3)纳米电分析化学
陈子轩,男,1987年生,南京大学化学化工学院副教授,博士生导师,基金委优秀青年科学基金获得者。
2015年博士毕业于南京大学化学化工学院,2016年起在南京大学工作,任副研究员,2021年起任副教授。主要研究方向为:1)光学显微仪器的研制;2)单细胞、单分子、单颗粒传感;3)纳米电分析化学。在Nat. Commun.、Sci. Adv.、J. Am. Chem. Soc.、Angew. Chem.等期刊上发表SCI论文30余篇,主持了国家优秀青年基金、面上项目等科研项目。
《仪器分析化学》
《仪器分析实验》
代表论文:
1. Tang, Z.; Wu, J.; Wu, S.; Tang, W.; Zhang, J.-R.; Zhu, W.; Zhu, J.-J.; Chen, Z., Single molecule–driven nanomotors reveal the dynamic-disordered chemomechanical transduction of active enzymes. Sci. Adv. 2025,11 (5), eads0446.
2. Chen, X.; Gao, Y.; Qi, Y.; Li, J.; Hu, T. Y.; Chen, Z.; Zhu, J.-J., Label-Free Raman Probing of the Intrinsic Electric Field for High-Efficiency Screening of Electricity-Producing Bacteria at the Single-Cell Level. Angew. Chem. Int. Ed. 2025,64 (4), e202416011.
3. Yang, R.; Cai, Y.; Qi, Y.; Tang, Z.; Zhu, J.-J.; Li, J.; Zhu, W.; Chen, Z., How local electric field regulates C–C coupling at a single nanocavity in electrocatalytic CO2 reduction. Nat. Commun. 2024,15 (1), 7140.
4. Gao, Y.; Wu, J.; Xia, Q.; Liu, J.; Zhu, J.-J.; Zhang, J.-R.; Chen, X.; Zhu, W.; Chen, Z., Operando Spectroscopic Elucidation of the Bubble Sunshade Effect in Inorganic–Biological Hybrids for Photosynthetic Hydrogen Production. ACS Nano 2024,18 (22), 14546-14557.
5. Wu, S.; Tang, W.; Wang, Z.; Tang, Z.; Zheng, P.; Chen, Z.; Zhu, J.-J., High Dynamic Range Probing of Single-Molecule Mechanical Force Transitions at Cell–Matrix Adhesion Bonds by a Plasmonic Tension Nanosensor. JACS Au 2024,4 (3), 1155-1165.
6. Xia, Q.; Liu, R.; Chen, X.; Chen, Z.; Zhu, J.-J., In Vivo Voltammetric Imaging of Metal Nanoparticle-Catalyzed Single-Cell Electron Transfer by Fermi Level-Responsive Graphene. Research 2023,6, 0145.
7. Gao, D.; Tang, Z.; Chen, X.; Wu, R.; Tian, Y.; Min, Q.; Zhang, J.-R.; Chen, Z.; Zhu, J.-J., Reversible Regulation of Long-Distance Charge Transport in DNA Nanowires by Dynamically Controlling Steric Conformation. Nano Lett. 2023,23 (10), 4201-4208.
8. Tang, Z.; Liu, R.; Chen, X.; Gao, D.; Zhang, J.-R.; Zhu, J.-J.; Chen, Z., Plasmonic Probing Single-Cell Bio-Current Waves with a Shrinking Magnetite Nanoprobe. ACS Nano 2022,16 (12), 20842-20850.
9. Chen, X.; Gao, Y.; Zhan, J.; Xia, Q.; Chen, Z.; Zhu, J.-J., Spatiotemporal-Resolved Hyperspectral Raman Imaging of Plasmon-Assisted Reactions at Single Hotspots. Anal. Chem. 2022,94 (23), 8174-8180.
10. Xia, Q.; Chen, X.; Liu, C.; Song, R.-B.; Chen, Z.; Zhang, J.; Zhu, J.-J., Label-Free Probing of Electron Transfer Kinetics of Single Microbial Cells on a Single-Layer Graphene via Structural Color Microscopy. Nano Lett. 2021,21 (18), 7823-7830.
11. Ma, C.; Wu, S.; Zhou, Y.; Wei, H.-F.; Zhang, J.; Chen, Z.; Zhu, J.-J.; Lin, Y.; Zhu, W., Bio-Coreactant-Enhanced Electrochemiluminescence Microscopy of Intracellular Structure and Transport. Angew. Chem. Int. Ed. 2021,60 (9), 4907-4914.
12. Ma, C.; Wei, H.-F.; Wang, M.-X.; Wu, S.; Chang, Y.-C.; Zhang, J.; Jiang, L.-P.; Zhu, W.; Chen, Z.; Lin, Y., Hydrogen Evolution Reaction Monitored by Electrochemiluminescence Blinking at Single-Nanoparticle Level. Nano Lett. 2020,20 (7), 5008-5016.
13. Xia, Q.; Chen, Z.; Xiao, P.; Wang, M.; Chen, X.; Zhang, J.-R.; Chen, H.-Y.; Zhu, J.-J., Fermi level-tuned optics of graphene for attocoulomb-scale quantification of electron transfer at single gold nanoparticles. Nat. Commun. 2019,10 (1), 3849.
14. Chen, X.; Xia, Q.; Cao, Y.; Min, Q.; Zhang, J.; Chen, Z.; Chen, H.-Y.; Zhu, J.-J., Imaging the transient heat generation of individual nanostructures with a mechanoresponsive polymer. Nat. Commun. 2017,8 (1), 1498.
15. Chen, Z.; Li, J.; Chen, X.; Cao, J.; Zhang, J.; Min, Q.; Zhu, J.-J., Single Gold@Silver Nanoprobes for Real-time Tracing the Entire Autophagy Process at Single-cell Level. J. Am. Chem. Soc. 2015,137 (5), 1903-1908.
2021-至今,南京大学化学化工学院,副教授
2016-2020年,南京大学化学化工学院,副研究员
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