1. Wang, C.; Yu, J.; Chen, H.; Hu, W.; Wang, H.; Liang, Y*.; Pan, H.-J.* Reprogramming Glutathione-Binding Proteins into Artificial Photoenzymes by Engineered Glutathione-Type Cofactors. J. Am. Chem. Soc. 2026, 148 (30), 31978-31988.
2. Wang, Q.; Zhang, B.; Wang, Y.; Xu, X.; Zuo, K.; Luo, J.; Fan, H.*; Li, Z.*; Pan, H.-J.*; Jiang, S.* A ROS-Responsive DNA Nanodevice for Targeted Cytosolic siRNA Delivery in Metabolic Dysfunction-Associated Steatohepatitis. J. Am. Chem. Soc. 2026, 148 (25), 26923-26937.
3. Wang, S.; Zhang, B.; Hu, W.; Wang, H.; Zhao, J.; Pan, H.-J.* Reprogramming NAD(P)+‐Binding Proteins for Iminium Biocatalysis via a Synthetic NAD+‐Type Cofactor. Angew. Chem. Int. Ed. 2026, 65 (30), e2116720.
4. Yu, J.; Wang, C.; Hu, W.; Wang, H.; Zhao, J.; Pan, H.-J.* Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme. Chem. Sci. 2026, 17(19), 9562–9569.
5. Li, J.; Du, P.; Zhou, T.-P.; Hu, W.; Li, H.; Wang, B*.; Pan, H.-J.* Enantioselective [2π+2σ] Cycloaddition to Bicyclo[2.1.1]hexanes Enabled by an Artificial Photoenzyme. J. Am. Chem. Soc. 2026, 148 (13), 13755–13763.
6. Chen, Q.; Yu, J.; Wang, C.; Zhao, J.; Pan, H.-J.* A Modular Cu(II)-Based Artificial Metalloenzyme for Enantioselective Lewis Acid Catalysis. ACS Catal. 2026. 16 (7), 6318–6325.
7. Du, P.; Li, J.; Zhou, T.-P.; Wang, J.; Hu, W.; Li, H.; Wang, B.*; Pan, H.-J.* An NAD⁺ analogue enables assembly of structurally diverse artificial photoenzymes for enantiodivergent [2 + 2] cycloadditions. Nat. Catal. 2025, 8 (8), 822–832.
8. Wang, C.; Li, H.; Li, J.; Wang, C.; Yu, J.; Shima, S.; Huang, G.*; Pan, H.-J.* Reconstitution of [Fe]-Hydrogenase with Model Complexes Reveals Functional Roles of Methyl Groups in the Metallocofactor. J. Am. Chem. Soc. 2025, 147 (27), 23758–23765.
9. Chen, Q. Q.; Yu, J. M.; Li, S. M.; Wang, C.; Zheng, P.; Pan, H.-J.* Stereocontrolled 1,3-Nitrogen Migration Catalyzed by Artificial Metalloenzymes Bearing Stereogenic Metal Centers. ChemCatChem 2025, 17 (16), e00901.
10. Wang, Y.; Lin, X.; Li, J.; Huang, G.*; Pan, H.-J.* Design, Synthesis and Activity Evaluation of Methylene‐H4MPT Mimics. Chem. Eur. J. 2025, 31 (27), e202500234.
11. Wang C.; Lai Z.; Huang G.*;Pan, H.-J.*, Current State of [Fe]-Hydrogenase and Its Biomimetic Models, Chem. Eur. J. 2022, 28, e202201499
12. Pan, H.-J.; Huang, G.; Wodrich, M. D.; Tirani, F. F.; Ataka, K.; Shima, S.*; and Hu, X.*, A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor, Nat. Chem. 2019, 11, 669-675.
13. Pan, H.-J.; Huang, G.; Tirani, F. F.; Ataka, K.; Shima, S.*; and Hu, X.*, Diversifying metal-ligand cooperative catalysis in semi‐synthetic [Mn]-hydrogenases, Angew. Chem. Int. Ed.2021, 60, 13350-13357.
14. Pan, H.-J.; and Hu, X.*, Biomimetic Hydrogenation Catalyzed by a Manganese Model of [Fe]-Hydrogenase, Angew. Chem. Int. Ed. 2020,59, 4942-4946.
15. Shi. R.; Wodrich, M. D.; Pan, H.-J.; Tirani, F. F.; and Hu, X.*, Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase, Angew. Chem. Int. Ed. 2019, 58, 16869-16872.
16. Pan, H.-J.#; Lin, Y.#; Gao, T.; Lau, K. K.; Feng, W.; Yang, B.;* Zhao, Y.*, Catalytic Diastereo- and Enantioconvergent Synthesis of Vicinal Diamines from Diols through Borrowing Hydrogen,Angew. Chem. Int. Ed.2021, 60, 18599-18604. (Pan, H.-J. and Lin, Y. contribute equally).
17. Pan, H.-J.; Zhang, Y.; Shan. C.; Yu, Z.; Lan, Y.; Zhao, Y.*, Asymmetric Transfer Hydrogenation of Imines using Alcohol: Efficiency and Selectivity Are Affected by the Hydrogen Donor, Angew. Chem. Int. Ed. 2016, 55, 9615-9619.
18. Arriaza Gallardo, F. J.; Schaupp, S.; Zheng, Y.-C.; Abdul-Halim M. F.; Pan, H.-J.; Kahnt, J.; Angelidou G.; Paczia, N.; Hu, X.; Costa, K.; Shima S., The Function of Two Radical-SAM Enzymes, HcgA and HcgG, in the Biosynthesis of the [Fe]-Hydrogenase Cofactor, Angew. Chem. Int. Ed. 2022, 61, e202213239
19. Schaupp, S.; Arriaza Gallardo, F. J.; Pan, H.-J.; Kahnt, J.; Angelidou, G.; Paczia, N.; Costa, K.; Hu, X.; Shima, S., In Vitro Biosynthesis of the [Fe]-Hydrogenase Cofactor Verifies the Proposed Biosynthetic Precursors, Angew. Chem. Int. Ed. 2022, 61, e202200994
20. Pan, H.-J.; Ng, T.-W.; Zhao, Y.*, Iron-catalyzed Transfer Hydrogenation of Imines Assisted by an Iron-Based Lewis Acid, Org. Biomol. Chem., 2016, 14, 5490-5493.
21. Pan, H.-J.; Ng, T.-W.; Zhao, Y.*, Iron-catalyzed Amination of Alcohols Assisted by Lewis Acid, Chem. Commun.2015,51, 11907-11910.
22. Ng, T. W.; Liao, G.; Lau, K. K.; Pan, H.-J.; Zhao, Y.*, Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity, Angew. Chem. Int. Ed. 2020, 59, 11384-11389
23. Rong, Z. Q.; Zhang, Y.; Chua, R. H. B.; Pan, H.-J.; Zhao, Y.*, Dynamic Kinetic Asymmetric Amination of Alcohols: From A Mixture of Four Isomers to Diastereo- and Enantiopure α-Branched Amines, J. Am. Chem. Soc.2015, 137, 4944-4947.
24. Zhang, Y.; Lim, C.-S.; Sim, D. S. B.; Pan, H.-J.; Zhao, Y.*, Catalytic Enantioselective Amination of Alcohols by the Use of Borrowing Hydrogen Methodology: Cooperative Catalysis by Iridium and a Chiral Phosphoric Acid, Angew. Chem. Int. Ed.2014, 53, 1399-1403.
25. Rong, Z.-Q.; Pan, H.-J.; Yan, H.-L.; Zhao, Y.*, Enantioselective Oxidation of 1, 2-Diols with Quinine-derived Urea Organocatalyst, Org. Lett.2014, 16, 208−211.
26. Pan, H.-J. #; Zhu, L. #; Li, J.; Zang, D.; Fu, Z.-S.*; Fan, Z.-Q., A Thermal Stable α-diimine Palladium Catalyst for Copolymerization of Ethylene with Functionalized Olefins, J. Mol. Catal. A: Chem.2014, 390, 76-82. (Pan, H.-J. and Zhu, L. contribute equally).
27. Zhu, L.; Fu, Z.-S.*; Pan, H.-J.; Feng, W.; Chen, C.; Fan, Z.-Q., Synthesis and Application of Binuclear α-diimine Nickel/Palladium Catalysts with a Conjugated Backbone, Dalton Trans., 2014, 43, 2900-2906.