潘惠杰，南京大学准聘副教授，特聘研究员，博士生导师。2012年本科毕业于浙江大学；2016年博士毕业于新加坡国立大学（NUS, 导师：赵宇教授）。2017-2021年在瑞士洛桑联邦理工学院（EPFL）从事博士后研究工作（合作导师：胡喜乐教授），期间获欧盟玛丽居里奖学金。2021年入职南京大学化学学院，同时加入南京大学化学和生物医药创新研究院以及配位化学全国重点实验室。入选国家高层次人才青年项目，担任国家重点研发计划首席青年科学家。主要研究方向为人工酶设计，不对称催化，合成生物学等。

课题组拟招聘博士后，科研助理若干。科研助理优先推荐来年博士申请。

课题组将以仿生合成、人工金属酶开发等为主要切入点，着眼于解决当前生物合成化学、有机合成化学中具有挑战性的问题，在生物催化、仿生催化、生物正交反应、不对称合成等方向开展研究，力争为医药、化工、能源、材料及生命科学等领域提供新的策略与技术手段。课题组具有充足的实验室空间及启动经费，欢迎有志于科研的青年加盟！

岗位要求

-博士后：具有以下某一方向研究经验的优秀博士：生物合成化学、分子生物学、蛋白设计和进化、有机合成，不对称催化等相关领域。

-研究助理：具有相关背景的硕士。

岗位职责

从事仿生化合物的合成，蛋白质设计表达优化，人工金属酶构建，酶催化机理探索，新型酶催化反应探索。完成课题组所要求的工作，形成高水平研究成果。

福利待遇

课题组将提供具有竞争力的薪酬待遇（特别优秀者年薪可高至40万/年），具体待遇面议。应聘者在职期间将享受南京大学规定的各项福利待遇，入选南京大学“毓秀青年学者计划”的博士后年薪最高可达60万/年。课题组将全力支持和协助研究助理及博士后未来的职业规划，表现优秀者可推荐进一步出国交流与深造。科研助理优先推荐来年博士生申请。

应聘材料

招聘需求长期有效。请将本人简历和研究总结，发送至导师邮箱huijie.pan@nju.edu.cn

1. Wang, C.; Yu, J.; Chen, H.; Hu, W.; Wang, H.; Liang, Y*.; Pan, H.-J.* Reprogramming Glutathione-Binding Proteins into Artificial Photoenzymes by Engineered Glutathione-Type Cofactors. J. Am. Chem. Soc. 2026, 148 (30), 31978-31988.

2. Wang, Q.; Zhang, B.; Wang, Y.; Xu, X.; Zuo, K.; Luo, J.; Fan, H.*; Li, Z.*; Pan, H.-J.*; Jiang, S.* A ROS-Responsive DNA Nanodevice for Targeted Cytosolic siRNA Delivery in Metabolic Dysfunction-Associated Steatohepatitis. J. Am. Chem. Soc. 2026, 148 (25), 26923-26937.

3. Wang, S.; Zhang, B.; Hu, W.; Wang, H.; Zhao, J.; Pan, H.-J.* Reprogramming NAD(P)+‐Binding Proteins for Iminium Biocatalysis via a Synthetic NAD+‐Type Cofactor. Angew. Chem. Int. Ed. 2026, 65 (30), e2116720.

4. Yu, J.; Wang, C.; Hu, W.; Wang, H.; Zhao, J.; Pan, H.-J.* Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme. Chem. Sci. 2026, 17(19), 9562–9569.

5. Li, J.; Du, P.; Zhou, T.-P.; Hu, W.; Li, H.; Wang, B*.; Pan, H.-J.* Enantioselective [2π+2σ] Cycloaddition to Bicyclo[2.1.1]hexanes Enabled by an Artificial Photoenzyme. J. Am. Chem. Soc. 2026, 148 (13), 13755–13763.

6. Chen, Q.; Yu, J.; Wang, C.; Zhao, J.; Pan, H.-J.* A Modular Cu(II)-Based Artificial Metalloenzyme for Enantioselective Lewis Acid Catalysis. ACS Catal. 2026. 16 (7), 6318–6325.

7. Du, P.; Li, J.; Zhou, T.-P.; Wang, J.; Hu, W.; Li, H.; Wang, B.*; Pan, H.-J.* An NAD⁺ analogue enables assembly of structurally diverse artificial photoenzymes for enantiodivergent [2 + 2] cycloadditions. Nat. Catal. 2025, 8 (8), 822–832.

8. Wang, C.; Li, H.; Li, J.; Wang, C.; Yu, J.; Shima, S.; Huang, G.*; Pan, H.-J.* Reconstitution of [Fe]-Hydrogenase with Model Complexes Reveals Functional Roles of Methyl Groups in the Metallocofactor. J. Am. Chem. Soc. 2025, 147 (27), 23758–23765.

9. Chen, Q. Q.; Yu, J. M.; Li, S. M.; Wang, C.; Zheng, P.; Pan, H.-J.* Stereocontrolled 1,3-Nitrogen Migration Catalyzed by Artificial Metalloenzymes Bearing Stereogenic Metal Centers. ChemCatChem 2025, 17 (16), e00901.

10. Wang, Y.; Lin, X.; Li, J.; Huang, G.*; Pan, H.-J.* Design, Synthesis and Activity Evaluation of Methylene‐H4MPT Mimics. Chem. Eur. J. 2025, 31 (27), e202500234.

11. Wang C.; Lai Z.; Huang G.*;Pan, H.-J.*, Current State of [Fe]-Hydrogenase and Its Biomimetic Models, Chem. Eur. J. 2022, 28, e202201499

12. Pan, H.-J.; Huang, G.; Wodrich, M. D.; Tirani, F. F.; Ataka, K.; Shima, S.*; and Hu, X.*, A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor, Nat. Chem. 2019, 11, 669-675.

13. Pan, H.-J.; Huang, G.; Tirani, F. F.; Ataka, K.; Shima, S.*; and Hu, X.*, Diversifying metal-ligand cooperative catalysis in semi‐synthetic [Mn]-hydrogenases, Angew. Chem. Int. Ed.2021, 60, 13350-13357.

14. Pan, H.-J.; and Hu, X.*, Biomimetic Hydrogenation Catalyzed by a Manganese Model of [Fe]-Hydrogenase, Angew. Chem. Int. Ed. 2020,59, 4942-4946.

15. Shi. R.; Wodrich, M. D.; Pan, H.-J.; Tirani, F. F.; and Hu, X.*, Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase, Angew. Chem. Int. Ed. 2019, 58, 16869-16872.

16. Pan, H.-J.#; Lin, Y.#; Gao, T.; Lau, K. K.; Feng, W.; Yang, B.;* Zhao, Y.*, Catalytic Diastereo- and Enantioconvergent Synthesis of Vicinal Diamines from Diols through Borrowing Hydrogen,Angew. Chem. Int. Ed.2021, 60, 18599-18604. (Pan, H.-J. and Lin, Y. contribute equally).

17. Pan, H.-J.; Zhang, Y.; Shan. C.; Yu, Z.; Lan, Y.; Zhao, Y.*, Asymmetric Transfer Hydrogenation of Imines using Alcohol: Efficiency and Selectivity Are Affected by the Hydrogen Donor, Angew. Chem. Int. Ed. 2016, 55, 9615-9619.

18. Arriaza Gallardo, F. J.; Schaupp, S.; Zheng, Y.-C.; Abdul-Halim M. F.; Pan, H.-J.; Kahnt, J.; Angelidou G.; Paczia, N.; Hu, X.; Costa, K.;  Shima S., The Function of Two Radical-SAM Enzymes, HcgA and HcgG, in the Biosynthesis of the [Fe]-Hydrogenase Cofactor,   Angew. Chem. Int. Ed. 2022, 61, e202213239

19. Schaupp, S.; Arriaza Gallardo, F. J.; Pan, H.-J.; Kahnt, J.; Angelidou, G.; Paczia, N.; Costa, K.; Hu, X.; Shima, S., In Vitro Biosynthesis of the [Fe]-Hydrogenase Cofactor Verifies the Proposed Biosynthetic Precursors, Angew. Chem. Int. Ed. 2022, 61, e202200994

20. Pan, H.-J.; Ng, T.-W.; Zhao, Y.*, Iron-catalyzed Transfer Hydrogenation of Imines Assisted by an Iron-Based Lewis Acid, Org. Biomol. Chem., 2016, 14, 5490-5493.

21. Pan, H.-J.; Ng, T.-W.; Zhao, Y.*, Iron-catalyzed Amination of Alcohols Assisted by Lewis Acid, Chem. Commun.2015,51, 11907-11910.

22. Ng, T. W.; Liao, G.; Lau, K. K.; Pan, H.-J.; Zhao, Y.*, Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity, Angew. Chem. Int. Ed. 2020, 59, 11384-11389

23. Rong, Z. Q.; Zhang, Y.; Chua, R. H. B.; Pan, H.-J.; Zhao, Y.*, Dynamic Kinetic Asymmetric Amination of Alcohols: From A Mixture of Four Isomers to Diastereo- and Enantiopure α-Branched Amines, J. Am. Chem. Soc.2015, 137, 4944-4947.

24. Zhang, Y.; Lim, C.-S.; Sim, D. S. B.; Pan, H.-J.; Zhao, Y.*, Catalytic Enantioselective Amination of Alcohols by the Use of Borrowing Hydrogen Methodology: Cooperative Catalysis by Iridium and a Chiral Phosphoric Acid, Angew. Chem. Int. Ed.2014, 53, 1399-1403.

25. Rong, Z.-Q.; Pan, H.-J.; Yan, H.-L.; Zhao, Y.*, Enantioselective Oxidation of 1, 2-Diols with Quinine-derived Urea Organocatalyst, Org. Lett.2014, 16, 208−211.

26. Pan, H.-J. #; Zhu, L. #; Li, J.; Zang, D.; Fu, Z.-S.*; Fan, Z.-Q., A Thermal Stable α-diimine Palladium Catalyst for Copolymerization of Ethylene with Functionalized Olefins, J. Mol. Catal. A: Chem.2014, 390, 76-82. (Pan, H.-J. and Zhu, L. contribute equally).

27. Zhu, L.; Fu, Z.-S.*; Pan, H.-J.; Feng, W.; Chen, C.; Fan, Z.-Q., Synthesis and Application of Binuclear α-diimine Nickel/Palladium Catalysts with a Conjugated Backbone, Dalton Trans., 2014, 43, 2900-2906.