Huijie obtained his B.E. in Polymer Science and Engineering from Zhejiang University in 2012, and Ph.D. in Organic Chemistry from  National University of Singapore in 2016 under the supervision of Prof. Yu Zhao. During his Ph.D., he mainly worked on chiral amine compounds synthesis via Borrowing Hydrogenation and Transfer Hydrogenation methodologies.  After a period of Research Assistant in the Zhao Group, Huijie joined the group of Prof. Xile Hu at EPFL Switzerland in May 2017, working on the biomimetic chemistry of [Fe]-hydrogenase and the development of artificial [Mn]-hydrogenase. In 2018, he was awarded Marie Skłodowska-Curie Individual Fellowships. From May 2021, Huijie started his independent career at Nanjing University as a member of the Department of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBic), and State Key Laboratory of Coordination Chemistry. His current research interests are Synthetic Biology, Biosynthesis, Artificial Enzymes, Biomimetic Chemistry, and Asymmetric Catalysis. 

1. Wang, C.; Yu, J.; Chen, H.; Hu, W.; Wang, H.; Liang, Y*.; Pan, H.-J.* Reprogramming Glutathione-Binding Proteins into Artificial Photoenzymes by Engineered Glutathione-Type Cofactors. J. Am. Chem. Soc. 2026, 148 (30), 31978-31988.

2. Wang, Q.; Zhang, B.; Wang, Y.; Xu, X.; Zuo, K.; Luo, J.; Fan, H.*; Li, Z.*; Pan, H.-J.*; Jiang, S.* A ROS-Responsive DNA Nanodevice for Targeted Cytosolic siRNA Delivery in Metabolic Dysfunction-Associated Steatohepatitis. J. Am. Chem. Soc. 2026, 148 (25), 26923-26937.

3. Wang, S.; Zhang, B.; Hu, W.; Wang, H.; Zhao, J.; Pan, H.-J.* Reprogramming NAD(P)+‐Binding Proteins for Iminium Biocatalysis via a Synthetic NAD+‐Type Cofactor. Angew. Chem. Int. Ed. 2026, 65 (30), e2116720.

4. Yu, J.; Wang, C.; Hu, W.; Wang, H.; Zhao, J.; Pan, H.-J.* Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme. Chem. Sci. 2026, 17(19), 9562–9569.

5. Li, J.; Du, P.; Zhou, T.-P.; Hu, W.; Li, H.; Wang, B*.; Pan, H.-J.* Enantioselective [2π+2σ] Cycloaddition to Bicyclo[2.1.1]hexanes Enabled by an Artificial Photoenzyme. J. Am. Chem. Soc. 2026, 148 (13), 13755–13763.

6. Chen, Q.; Yu, J.; Wang, C.; Zhao, J.; Pan, H.-J.* A Modular Cu(II)-Based Artificial Metalloenzyme for Enantioselective Lewis Acid Catalysis. ACS Catal. 2026. 16 (7), 6318–6325.

7. Du, P.; Li, J.; Zhou, T.-P.; Wang, J.; Hu, W.; Li, H.; Wang, B.*; Pan, H.-J.* An NAD⁺ analogue enables assembly of structurally diverse artificial photoenzymes for enantiodivergent [2 + 2] cycloadditions. Nat. Catal. 2025, 8 (8), 822–832.

8. Wang, C.; Li, H.; Li, J.; Wang, C.; Yu, J.; Shima, S.; Huang, G.*; Pan, H.-J.* Reconstitution of [Fe]-Hydrogenase with Model Complexes Reveals Functional Roles of Methyl Groups in the Metallocofactor. J. Am. Chem. Soc. 2025, 147 (27), 23758–23765.

9. Chen, Q. Q.; Yu, J. M.; Li, S. M.; Wang, C.; Zheng, P.; Pan, H.-J.* Stereocontrolled 1,3-Nitrogen Migration Catalyzed by Artificial Metalloenzymes Bearing Stereogenic Metal Centers. ChemCatChem 2025, 17 (16), e00901.

10. Wang, Y.; Lin, X.; Li, J.; Huang, G.*; Pan, H.-J.* Design, Synthesis and Activity Evaluation of Methylene‐H4MPT Mimics. Chem. Eur. J. 2025, 31 (27), e202500234.

11. Wang C.; Lai Z.; Huang G.*;Pan, H.-J.*, Current State of [Fe]-Hydrogenase and Its Biomimetic Models, Chem. Eur. J. 2022, 28, e202201499

12. Pan, H.-J.; Huang, G.; Wodrich, M. D.; Tirani, F. F.; Ataka, K.; Shima, S.*; and Hu, X.*, A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor, Nat. Chem. 2019, 11, 669-675.

13. Pan, H.-J.; Huang, G.; Tirani, F. F.; Ataka, K.; Shima, S.*; and Hu, X.*, Diversifying metal-ligand cooperative catalysis in semi‐synthetic [Mn]-hydrogenases, Angew. Chem. Int. Ed.2021, 60, 13350-13357.

14. Pan, H.-J.; and Hu, X.*, Biomimetic Hydrogenation Catalyzed by a Manganese Model of [Fe]-Hydrogenase, Angew. Chem. Int. Ed. 2020,59, 4942-4946.

15. Shi. R.; Wodrich, M. D.; Pan, H.-J.; Tirani, F. F.; and Hu, X.*, Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase, Angew. Chem. Int. Ed. 2019, 58, 16869-16872.

16. Pan, H.-J.#; Lin, Y.#; Gao, T.; Lau, K. K.; Feng, W.; Yang, B.;* Zhao, Y.*, Catalytic Diastereo- and Enantioconvergent Synthesis of Vicinal Diamines from Diols through Borrowing Hydrogen,Angew. Chem. Int. Ed.2021, 60, 18599-18604. (Pan, H.-J. and Lin, Y. contribute equally).

17. Pan, H.-J.; Zhang, Y.; Shan. C.; Yu, Z.; Lan, Y.; Zhao, Y.*, Asymmetric Transfer Hydrogenation of Imines using Alcohol: Efficiency and Selectivity Are Affected by the Hydrogen Donor, Angew. Chem. Int. Ed. 2016, 55, 9615-9619.

18. Arriaza Gallardo, F. J.; Schaupp, S.; Zheng, Y.-C.; Abdul-Halim M. F.; Pan, H.-J.; Kahnt, J.; Angelidou G.; Paczia, N.; Hu, X.; Costa, K.;  Shima S., The Function of Two Radical-SAM Enzymes, HcgA and HcgG, in the Biosynthesis of the [Fe]-Hydrogenase Cofactor,   Angew. Chem. Int. Ed. 2022, 61, e202213239

19. Schaupp, S.; Arriaza Gallardo, F. J.; Pan, H.-J.; Kahnt, J.; Angelidou, G.; Paczia, N.; Costa, K.; Hu, X.; Shima, S., In Vitro Biosynthesis of the [Fe]-Hydrogenase Cofactor Verifies the Proposed Biosynthetic Precursors, Angew. Chem. Int. Ed. 2022, 61, e202200994

20. Pan, H.-J.; Ng, T.-W.; Zhao, Y.*, Iron-catalyzed Transfer Hydrogenation of Imines Assisted by an Iron-Based Lewis Acid, Org. Biomol. Chem., 2016, 14, 5490-5493.

21. Pan, H.-J.; Ng, T.-W.; Zhao, Y.*, Iron-catalyzed Amination of Alcohols Assisted by Lewis Acid, Chem. Commun.2015,51, 11907-11910.

22. Ng, T. W.; Liao, G.; Lau, K. K.; Pan, H.-J.; Zhao, Y.*, Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity, Angew. Chem. Int. Ed. 2020, 59, 11384-11389

23. Rong, Z. Q.; Zhang, Y.; Chua, R. H. B.; Pan, H.-J.; Zhao, Y.*, Dynamic Kinetic Asymmetric Amination of Alcohols: From A Mixture of Four Isomers to Diastereo- and Enantiopure α-Branched Amines, J. Am. Chem. Soc.2015, 137, 4944-4947.

24. Zhang, Y.; Lim, C.-S.; Sim, D. S. B.; Pan, H.-J.; Zhao, Y.*, Catalytic Enantioselective Amination of Alcohols by the Use of Borrowing Hydrogen Methodology: Cooperative Catalysis by Iridium and a Chiral Phosphoric Acid, Angew. Chem. Int. Ed.2014, 53, 1399-1403.

25. Rong, Z.-Q.; Pan, H.-J.; Yan, H.-L.; Zhao, Y.*, Enantioselective Oxidation of 1, 2-Diols with Quinine-derived Urea Organocatalyst, Org. Lett.2014, 16, 208−211.

26. Pan, H.-J. #; Zhu, L. #; Li, J.; Zang, D.; Fu, Z.-S.*; Fan, Z.-Q., A Thermal Stable α-diimine Palladium Catalyst for Copolymerization of Ethylene with Functionalized Olefins, J. Mol. Catal. A: Chem.2014, 390, 76-82. (Pan, H.-J. and Zhu, L. contribute equally).

27. Zhu, L.; Fu, Z.-S.*; Pan, H.-J.; Feng, W.; Chen, C.; Fan, Z.-Q., Synthesis and Application of Binuclear α-diimine Nickel/Palladium Catalysts with a Conjugated Backbone, Dalton Trans., 2014, 43, 2900-2906.