甄叙
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办公地址: 化学楼D403
电子邮箱: zhenxu@nju.edu.cn
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个人简介

甄叙,男,南京大学化学化工学院高分子化学与物理系特聘研究员,博士生导师,国家级青年人才项目入选者。2009年本科毕业于南开大学化学学院。2014年博士毕业于南京大学化学化工学院高分子化学与物理专业,导师蒋锡群教授。2014-2018年先后在新加坡国立大学化学与生物分子工程系(合作导师:Wang Chi-Hwa教授)和南洋理工大学化学与生物医药工程系(合作导师:浦侃裔教授)从事博士后研究工作。2019年获得南京大学“登峰计划”B层次人才引进,入职南京大学化学化工学院高分子化学与物理系。从事的研究方向为生物医用高分子材料的设计合成及其在疾病诊断和治疗中的应用。目前已在Nat. Biotechnol., Nat. Commun., Angew. Chem. Int. Ed., Adv. Mater., Nano Lett., ACS Nano 等学术刊物上发表论文五十余篇,论文引用5000余次,H因子39 (截止至2020年11月)


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工作经历

2014-2015 新加坡国立大学化学与生物分子工程系,助理研究员

2015-2018 南洋理工大学化学与生物医药工程系,助理研究员

2019-至今 南京大学化学化工学院高分子化学与物理系,特聘研究员,博士生导师

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研究方向

生物医用高分子材料的设计及生物医学应用,包括半导体共轭聚合物和有机高分子光学探针的设计合成及生物医学应用。


学术成果

(*: corresponding author; #: equal contribution)

2021

56. Xin Wang, Xu Zhen*, Xiqun Jiang*.Semiconducting polymer nanoparticles for optical imaging: self-luminescence imaging and photoacoustic imaging. Acta Polymerica Sinica (高分子学报),2021,doi: 10.11777/j.issn1000-3304.2021.21019.(特约专论)

55. Xu Zhen,  Kanyi Pu*, Xiqun Jiang*. Photoacoustic imaging and photothermal therapy of  semiconducting polymer nanoparticles: signal amplification and second near-infrared construction. Small2021, 2004723.

54. Ying Lin, Cheng Li, An Liu, Xu Zhen, Jiangang Gao, Wei Wu, Weibo Cai, Xiqun Jiang*. Responsive hyaluronic acid-gold clusters hybrid nanogel theranostic system. Biomaterials Science, 2021, 9, 1363-1373.

53. Xu Zhen#, Rui Qu#, Weizhi Chen#,  Wei Wu, Xiqun Jiang*. Development of phosphorescent probes for in vitro and in vivo bioimaging. Biomaterials Science, 2021, 9, 285-300. (Front Cover) (Hot Article

2020

52.Weizhi Chen#, Xu Zhen#, Wei Wu, Xiqun Jiang*. Responsive boron biomaterials and their biomedical applications. Science China Chemistry, 2020, 63, 648-664.

51.Xu Zhen, Xiqun Jiang*. Polymer-based activatable optical probes for tumor fluorescence and photoacoustic imaging. WIREs Nanomedicine and Nanobiotechnology, 2020, 1593.

2019

50.Xiaoping Qian, Lei Ge, Kangjun Yuan, Cheng Li, Xu Zhen, Weibo Cai, Rongshi Cheng, Xiqun Jiang*. Targeting and microenvironment-improving of phenylboronic acid-decorated soy protein nanoparticles with different sizes to tumor. Theranostics, 2019, 9, 7417-7430.

BEFORE JOINING NJU

2019

49.Xu Zhen, Penghui Cheng, Kanyi Pu*. Recent advances in cell membrane–camouflaged nanoparticles for cancer phototherapySmall, 2019, 15, 1970002. (Cover Feature) (ESI high cited paper)

48.Zhimin Wang, Xu Zhen, Paul Kumar Upputuri, Yuyan Jiang, Junwei Lau, Manojit Pramanik, Kanyi Pu*, Bengang Xing*. Redox-activatable and acid-enhanced nanotheranostics for second near-infrared photoacoustic tomography and combined photothermal tumor therapyACS Nano, 2019, 13, 5816-5825.

47.Yuyan Jiang, Jiaguo Huang, Xu Zhen, Ziling Zeng, Jingchao Li, Chen Xie, Qingqing Miao, Jie Chen, Peng Chen, Kanyi Pu*. A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nature Communications, 2019, 10, 2064.

46.Dong Cui, Jiaguo Huang, Xu Zhen, Jingchao Li, Yuyan Jiang, and Kanyi Pu*. A semiconducting polymer nano-prodrug for hypoxia-activated photodynamic cancer therapy. Angewandte Chemie International Edition, 2019, 58, 5920 –5924.

45.Dong Cui, Pengcheng Li, Xu Zhen, Jingchao Li, Yuyan Jiang, Aixi Yu*, Xiang Hu*, Kanyi Pu*. Thermoresponsive Semiconducting polymer nanoparticles for contrast-enhanced photoacoustic imaging. Advanced Functional Materials, 2019, 29, 1903461.

44.Zhimin Wang, Paul Kumar Upputuri, Xu Zhen, Ruochong Zhang, Yuyan Jiang, Xiangzhao Ai, Zhijun Zhang, Ming Hu, Zhenyu Meng, Yunpeng Lu, Yuanjing Zheng, Kanyi Pu*, Manojit Pramanik*, Bengang Xing*. PH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging. Nano Research, 2019, 12, 49–55.

43.Yuyan Jiang, Paul Kumar Upputuri, Chen Xie, Ziling Zeng, Arunima Sharma, Xu Zhen, Jingchao Li, Jiaguo Huang, Manojit Pramanik, Kanyi Pu*. Metabolizable semiconducting polymer nanoparticles for second nearinfrared photoacoustic imagingAdvanced Materials, 2019, 1808166.

2018

42.Xu Zhen, Chen Xie, Kanyi Pu*. Temperature-correlated afterglow of a semiconducting polymer nanococktail for imaging-guided photothermal therapy. Angewandte Chemie International Edition, 2018, 57, 3938-3942. (Very Important Paper(ESI high cited paper)

41.Xu Zhen, Jianjian Zhang, Jiaguo Huang, Chen Xie, Qingqing Miao, Kanyi Pu*. Macrotheranostic probe with disease-activated near-infrared fluorescence, photoacoustic and photothermal signals for imaging-guided therapy. Angewandte Chemie International Edition, 2018, 57, 7804-7808.(ESI high cited paper)

40.Xu Zhen,Chen Xie, Yuyan Jiang, Xiangzhao Ai, Bengang Xing, Kanyi Pu*. Semiconducting photothermal nanoagonist for remote-controlled specific cancer therapy. Nano Letters, 2018, 18, 1498–1505.(ESI high cited paper)

39.Xu Zhen, Kanyi Pu*. Development of optical nanoprobes for molecular imaging of reactive oxygen and nitrogen species. Nano Research, 2018, 11, 5258-5280.

38.Jie Yang, Xu Zhen, Bin Wang, Xuming Gao, Zichun Ren, Jiaqiang Wang, Yujun Xie, Jian-Rong Li, Qian Peng, Kanyi Pu*, Zhen Li*. The influence of the molecular packing on the room temperature phosphorescence of purely organic luminogens. Nature Communications, 2018, 9, 840. 

37.Chen Xie, Xu Zhen, Qingqing Miao, Yan Lyu, Kanyi Pu*. Self-assembled semiconducting polymer nanoparticles for ultrasensitive near-infrared afterglow imaging of metastatic tumors. Advanced Materials, 2018, 30, 1801331.

36.Jingchao Li, Xu Zhen, Yan Lyu, Yuyan Jiang, Jiaguo Huang, Kanyi Pu*. Cell membrane coated semiconducting polymer nanoparticles for enhanced multimodal cancer phototheranostics. ACS Nano, 2018, 12 8520-8530.

35.Jianjian Zhang, Xu Zhen, Jianfeng Zeng*, Kanyi Pu*. A dual-modal molecular probe for near-infrared fluorescence and photoacoustic imaging of peroxynitrite. Analytical Chemistry, 2018, 90, 9301-9307.

34.Yuyan Jiang, Jingchao Li, Xu Zhen, Chen Xie, Kanyi Pu*. Dual-peak absorbing semiconducting copolymer nanoparticles for first and second near-infrared window photothermal therapy: a comparative study. Advanced Materials, 2018, 30, 1705980.

33.Chen Xie, Yan Lyu, Xu Zhen, Qingqing Miao, Kanyi Pu*. Activatable semiconducting oligomer amphiphile for near-infrared luminescence imaging of biothiols. ACS Applied Bio Materials, 2018, 1, 1147-1153.

32.Yan Lyu, Jianfeng Zeng, Yuyan Jiang, Xu Zhen, Shanshan Qiu, Ting Wang, Xin Lou, Mingyuan Gao*, Kanyi Pu*. Enhancing both biodegradability and efficacy of semiconducting polymer nanoparticles for photoacoustic imaging and photothermal therapy. ACS Nano, 2018, 12, 1801-1810.

31.Jiajing Zhou, Yuyan Jiang, Shuai Hou, Paul Kumar Upputuri, Di Wu, Jingchao Li, Peng Wang, Xu Zhen, Manojit Pramanik, Kanyi Pu*, Hongwei Duan*. Compact plasmonic blackbody for cancer theranosis in the near-infrared II window. ACS Nano, 2018, 12, 2643-2651.

2017

30.Xu Zhen, Ye Tao, Zhongfu An, Peng Chen, Chenjie Xu, Runfeng Chen*, Wei Huang*, Kanyi Pu*. Ultralong phosphorescence of water-soluble organic nanoparticles for in vivo afterglow imaging. Advanced Materials, 2017, 29, 1606665. (Cover Feature) (ESI high cited paper)

29.Xu Zhen, Xiaohua Feng, Chen Xie, Yuanjin Zheng, Kanyi Pu*. Surface engineering of semiconducting polymer nanoparticles for amplified photoacoustic imaging. Biomaterials, 2017, 127, 97–106.

28.Xu Zhen, Weicheng Ng, Fendy, Yen Wah Tong, Yanjun Dai*, Koon Gee Neoh*, Chi-Hwa Wang*. Toxicity assessment of carbon black waste: a by-product from oil refineries. Journal of Hazardous Materials, 2017, 321, 600-610.

27.Jianjian Zhang#, Xu Zhen#, Paul Kumar Upputuri, Manojit Pramanik, Peng Chen, Kanyi Pu*. Activatable photoacoustic nanoprobes for in vivo ratiometric imaging of peroxynitrite. Advanced Materials, 2017, 29, 1604764. (Cover Feature(ESI high cited paper)

26.Chao Yin#,Xu Zhen#, Quli Fan*, Wei Huang*, Kanyi Pu*. Degradable semiconducting oligomer amphiphile for ratiometric photoacoustic imaging of hypochlorite. ACS Nano, 2017, 11, 4174–4182. (ESI high cited paper)

25.Houjuan Zhu#, Zhuangchai Lai#, Yuan Fang#, Xu Zhen#, Chaoliang Tan, Xiaoying Qi, Dan Ding*, Peng Chen*, Hua Zhang*, Kanyi Pu*. Ternary chalcogenide nanosheets with ultrahigh phototherml conversion efficiency for photoacoustic theranostics. Small, 2017, 13, 1604139.

24.Chen Xie, Xu Zhen,Yan Lyu, Kanyi Pu*. Nanoparticle regrowth enhances photoacoustic signals of semiconducting macromolecular probe for in vivo imaging. Advanced Materials, 2017, 29, 1703693.

23.Yan Lyu, Xu Zhen, Yansong Miao, Kanyi Pu*. Reactivity-based semiconducting polymer nanoprobes for photoacoustic imaging of protein sulfenic acids. ACS Nano, 2017, 11, 358–367.

22.Chen Xie, Xu Zhen, Qunli Lei, Ran Ni, Kanyi Pu*. Self-assembly of semiconducting polymer amphiphiles for in vivo photoacoustic imaging. Advanced Functional Materials, 2017, 27, 1605397.

21.Chao Yin, Xu Zhen, Hui Zhao, Yufu Tang, Yu Ji, Yan Lyu, Quli Fan*, Wei Huang*, Kanyi Pu*. Amphiphilic semiconducting oligomer for near-infrared photoacoustic and fluorescence imaging. ACS Applied Materials & Interfaces, 2017, 9, 12332-12339.

20.Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V. Jokerst, Kanyi Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nature Biotechnology, 2017, 35, 1102–1110.

19.Svetlana Chechetka, Yue Yu, Xu Zhen, Manojit Pramanik, Kanyi Pu*, Eijiro Miyako*. Light-driven liquid metal nanotransformers for biomedical theranostics. Nature Communications, 2017, 8, 15432.

18.Chen Xie, Paul Kumar Upputuri, Xu Zhen, Manojit Pramanik, Kanyi Pu*. Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging. Biomaterials, 2017, 119, 1-8.

17.Yuyan Jiang, Dong Cui, Yuan Fang, Xu Zhen, Paul Kumar Upputuri, Manojit Pramanik, Dan Ding, Kanyi Pu*. Amphiphilic semiconducting polymer as multifunctional nanocarrier for fluorescence/photoacoustic imaging guided chemo-photothermal therapy. Biomaterials, 2017, 145, 168-177.

16.Pengwei Dong, Thawatchai Maneerung, Weicheng Ng, Xu Zhen, Yanjun Dai, Yen Wah Tong, Yen-Peng Ting, Shin Nuo Koh, Chi-Hwa Wang*, Koon Gee Neoh*. Chemically treated carbon black waste and its potential applications. Journal of Hazardous Materials, 2017, 321, 62-72.

15.Dong Cui, Chen Xie, Yan Lyu, Xu Zhen, Kanyi Pu*. Near-infrared absorbing amphiphilic semiconducting polymers for photoacoustic imaging. Journal of Materials Chemistry B, 2017, 5, 4406-4409.

2016

14.Xu Zhen, Chengwu Zhang, Chen Xie, Qingqing Miao, Kah-Leong Lim, Kanyi Pu*. Intraparticle energy level alignment of semiconducting polymer nanoparticles to amplify chemiluminescence for ultrasensitive in vivo imaging of reactive oxygen species. ACS Nano, 2016, 10, 6400–6409.(ESI high cited paper)

13.Xu Zhen, Le Rong, Weicheng Ng, Sam Fong Yau Li, Yanjun Dai, Yen Wah Tong, Koon Gee Neoh*, Chi-Hwa Wang*. Rapid toxicity screening of gasification ashes. Waste Management, 2016, 50, 93-104.

12.Houjuan Zhu#, Yuan Fang#, Xu Zhen#, Na Wei, Yu Gao, Kathy Qian Luo, Chenjie Xu, Hongwei Duan, Dan Ding*, Peng Chen*, Kanyi Pu*. Multilayered semiconducting polymer nanoparticles with enhanced NIR fluorescence for molecular imaging in cells, zebrafish and mice. Chemical Science, 2016, 8, 5118-5125.

11.Yan Lyu, Yuan Fang, Qingqing Miao, Xu Zhen, Dan Ding*, Kanyi Pu*. Intraparticle molecular orbital engineering of semiconducting polymer nanoparticles as amplified theranostics for in vivo photoacoustic imaging and photothermal therapy. ACS Nano, 2016, 10, 4472-4481.

2015

10.Hongling Li, Yingjie Tay, Siu Hon Tsang, Xu Zhen, Edwin Hang Tong Teo*. Controllable synthesis of highly luminescent boron nitride quantum dots. Small, 2015, 11, 6491-6499.

2014

9.   Xu Zhen, Xin Wang, Chenchen Yang, Qin Liu, Wei Wu, Baorui Liu, Xiqun Jiang*. Synthesis, cellular uptake and biodistribution of whey-rich nanoparticles. Macromolecular Bioscience, 2014, 14, 1149-1159.

8.   Xin Wang, Chenchen Yang, Yajun Zhang, Xu Zhen, Wei Wu, Xiqun Jiang*. Delivery of platinum (IV) drug to subcutaneous tumor and lung metastasis using bradykinin-potentiating peptide-decorated chitosan nanoparticles. Biomaterials, 2014, 35, 6439-6453.

2013

7. Xu Zhen, Xin Wang, Chen Xie, Wei Wu, Xiqun Jiang*. Cellular uptake, antitumor response and tumor penetration of cisplatin-loaded milk protein nanoparticles. Biomaterials, 2013, 34, 1372-1382.

6. Xin Wang, Xu Zhen, Jing Wang, Jialiang Zhang, Wei Wu, Xiqun Jiang*. Doxorubicin delivery to 3D culticellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles. Biomaterials, 2013, 34, 4667-4679.

5. Shuling Yu, Yajun Zhang, Xin Wang, Xu Zhen, Zhaoheng Zhang, Wei Wu, Xiqun Jiang*. Synthesis of paclitaxel-conjugated β-Cyclodextrin polyrotaxane and its antitumor activity. Angewandte Chemie International Edition, 2013, 52, 7272-7277.

4. Puyuan Wu, Qin Liu, Rutian Li, Jing Wang, Xu Zhen, Mi Yang, Xiaoping Qian, Lixia Yu, Xiqun Jiang*, Baorui Liu*. Facile preparation of paclitaxel loaded silk fibroin nanoparticles for enhanced antitumor efficacy by locoregional drug delivery. ACS Applied Materials & Interfaces, 2013, 23, 12638-12645.

2012

3. Yuan Cheng, Shuling Yu, Xu Zhen, Xin Wang, Wei Wu, Xiqun Jiang*. Alginic acid nanoparticles prepared through counterion complexation method as a drug delivery system. ACS Applied Materials & Interfaces, 2012, 4, 5325-5332.

2011

2. Chengjie Liu, Xu Zhen, Xin Wang, Wei Wu, Xiqun Jiang*. Cellular entry fashion of hollow milk protein spheres. Soft Matter, 2011, 24, 11526-11534.

1. Zhenshu Zhu, Chen Xie, Qin Liu, Xu Zhen, Xianchuang Zheng, Wei Wu, Rutian Li, Yin Ding, Xiqun Jiang*, Baorui Liu. The effect of hydrophilic chain length and iRGD on drug delivery from poly (ε-caprolactone)-poly (N-vinylpyrrolidone) nanoparticles. Biomaterials, 2011, 32, 9525-9535.

课程名称、上课时间地点

2020-2021学年第一学期,高分子导论,周二第1-2节,仙1-116


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