我是谁：身体地上爬，精神漫天飘

普通人，好奇心强，热爱生活、博物、音乐与阅读，父母与亲人，

但无力挣脱人性的弱点、欲望与枷锁。

经历过系统性“高等教育训练”，可从事智力型工作，略懂科学方法论和糖科学，

相信科学就是勤奋、实事求是和逻辑迭代训练，能用有限认知部分解释大千世界之一隅。

相信情感与美是理性的终极奥义，自身仍有很多需要改造的「矫情」「过度思虑」和「认知差异」。

羡慕从前慢和古君子的黄老庄拥趸，「道」「法」「自然」，

顺势而往往不为，随性但有失洒脱，常嗟叹人生苦短，希冀最大体验。

心底善良，待人以诚，能「直抒」块垒，有容人之心，

有奇怪但可解释幽默感（但不乏毒舌），情商及社交能力长期堪忧且无意改变。

相信平等自由，喜欢和年轻人交流，十分留恋部分学生眼底的「一抹星光」。

自知无权介入他人的因果，但往往会因此自责。

师”字，“帅”字上面一横。能带领，能统率，但一定要忍住不干，让学生干,

鼓励TA们发挥最大主观能动性, 让TA们在硅基时代寻觅智人思想，找到属于自己的路，

目前：

一笑悬命，日日是好日，学习抱怨着与世界和解。

Stay hungry and foolish, yet a fat-ass anyway.

省流：请在微信中搜索“谢然课题组”寻觅官方信息。

做一些能做的，想做的事。

1） 撰写糖科学史，为了忘却的纪念，需要时间精力和耐心，一点点来.

2） 鞘翅目金龟科部分类群收集定种，包括但不限于兜锹花臂蜣.

3） 学术，可以姑且谓之“化学糖生物学”。

a) 新型非天然糖代谢标记探针的开发及应用 

b) 疾病模型中的糖分析检测及生物学功能阐释

c) 基于非天然氨基酸插入技术的糖酶改造及功能调控

d) 革兰氏阴性菌脂多糖转运蛋白的体外重构及功能解析 

感谢国家，提供客观基础

感谢学生，不负韶华易老

感谢合作，开脑洞玩科研

感谢时光，凝固起起落落

2026

1.   Wei Cao, Wenkai Liu, Ming Yang, Luyao Yu, Ting Li, Yao Zhou, Xiaocui Zheng, Li Yi, Han Wang, Leyi Li, Chang Xu, Yi Hsu, Jiaming Jin, Senlian Hong*, Yixuan Xie*, Wei Wang*, Jiajia Wang*, and Ran Xie* (2026). Bioorthogonal Heptose Phosphate Probes for Chemical Profiling of Bacterial Glycans. JACS Au, https://doi.org/10.1021/jacsau.6c00391

2.   Xiaocui Zheng, Wanqing Wei, Changjiang Wang, Yingdan Du, Jing Yang, Yao Zhou, Ying Liu, Yong Liang, Lijun Ding, and Ran Xie* (2026). A Photoactivatable Glycoenzyme Platform for Spatiotemporally Controlled, Protein-Selective, and In Vivo Glycan Editing. J. Am. Chem. Soc., 148(10), 10990-11000. https://doi.org/10.1021/jacs.5c21919

3. Nana Li, Yida Han, Jie Wang, Yuqin Xu, Zongjun Tang, Ran Xie*, Jing-Juan Xu, and Li-Qing Zheng* (2026). Nanoscale Chemical Imaging of Functionalized Monosaccharides Via Click-Chemistry by Tip-Enhanced Raman Spectroscopy. J. Phys. Chem. Lett., https://pubs.acs.org/doi/10.1021/acs.jpclett.6c01651

4. Yuyang Tian, Yinxing Miao, Pengke Zhao, Lian Wang, Xiangdong He, Huiyu Chen, Zhiyuan Feng, Jinglang Gong, Xiaolian Sun, Jingjing Zhang, Ran Xie, Min Feng, Deju Ye; An Enzymatic in situ Self-Assembly Radiosensitizer for Hypoxic Tumor Radio-Immunotherapy via Low-Power X-ray-Induced Pyroptosis. Journal American Chemical Society 2 September 2026; 148 (34): 37407–37423. https://doi.org/10.1021/jacs.6c13005

2025

1. Liu, C., Zhang, H., Mao, J. et al. Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases. Nat Aging (2025). https://doi.org/10.1038/s43587-025-00946-7

2. Wang, Yichun, et al. Glycan Covalent Targeting Chimera‐Based T‐Cell Glycoengineering for Boosting Immunotherapy. Chemistry–A European Journal 31.30 (2025): e202500364. https://doi.org/10.1002/chem.202500364

2024

1. Meng, Xiangfeng, Yue Zhou, Lei Xu, Limu Hu, Changjiang Wang, Xiao Tian, Xiang Zhang et al. O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression. ACS Central Science 10, no. 5 (2024): 1065-1083.

2.Guo, Linru, Yida Han, Hong Yang, Jie Fu, Wang Li, Ran Xie, Yuanjian Zhang, Kang Wang, and Xing-Hua Xia. Single-Molecule Discrimination of Saccharides Using Carbon Nitride Nanopores. Nano Letters 24, no. 18 (2024): 5639-5646.

3.Yao, Yunyan, Ru Jia, Chuanming Liu, Haiqi Wang, Ting Li, Xiaocui Zheng, Tong Zhong et al. An in‐situ‐tag‐generation proximity labeling technology for recording cellular interactions. Angewandte Chemie (2024): e202407109.

4. Wang, G., Wang, Y., Wang, L., Wu, S., Cao, A., Pu, W., Li, T., Xie, R., Wang, H., Ding, L. and Ju, H., 2024. Stressor-Actuated Proximity Labeling for Reporting Cellular Interaction. Analytical Chemistry.

5. Xu, L., Zhao, W., Wang, R., Hong, M., Wang, H., Sun, Y., Zhong, T., Hang, D., Xie, R., Chen, L. and Yao, B., 2024. Aglycone Analysis and Quantitative Tracking of Correlated Terminal Glycan Pair on Spermatozoa. Analytical Chemistry, 96(41), pp.16186-16194.

6. Xu, H., Ye, J., Zhang, K.X., Hu, Q., Cui, T., Tong, C., Wang, M., Geng, H., Shui, K.M., Sun, Y. and Wang, J., 2024. Chemoproteomic profiling unveils binding and functional diversity of endogenous proteins that interact with endogenous triplex DNA. Nature Chemistry, 16(11), pp.1811-1821.

2023 

1. Xiao Tian; Lingna Zheng; Changjiang Wang; Yida Han; Yujie Li; Tongxiao Cui; Jialin Liu; Chuanming Liu; Guogeng Jia; Lujie Yang; Yi Hsu; Chen Zeng; Lijun Ding; Chu Wang; Bo Cheng; Meng Wang*; Ran Xie*(2023) Selenium-based metabolic oligosaccharide engineering strategy for quantitative glycan detection, Nature Communications, 14(1) 8281, https://doi.org/10.1038/s41467-023-44118-w

2. Yihong Zhong, Lijia Xu, Chen Yang, Le Xu, Guyu Wang, Yuna Guo, Songtao Cheng, Xiao Tian, Changjiang Wang, Ran Xie, Xiaojian Wang, Lin Ding, Huangxian Ju (2023). Site-selected in situ polymerization for living cell surface engineering. Nature Communications, https://doi.org/10.1038/s41467-023-43161-x

3. Yi Man,# Di Lu# and Ran Xie* (2023). State-of-the-Art Imaging Tool Portray the Role of GlycoRNAs in Cancer-and Immuno-Biology. (Viewpoint). Chem. Biomed. Imaging2023, 1, 7, 667-669.,https://doi.org/10.1021/cbmi.3c00099

4. Xiaocui Zheng, Yiran Li, Tongxiao Cui, Jing Yang, Xiangfeng Meng, Haiqi Wang, Liusheng Chen, Jian He, Nan Chen, Liying Meng,* Lin Ding,* and Ran Xie* (2023). Traceless Protein-Selective Glycan Labeling and Chemical Modification. J. Am. Chem. Soc., https://doi.org/10.1021/jacs.3c07889

5. Xiaocui Zheng, Boqiang He,  Liying Meng,* and Ran Xie* (2023). Recent Advances in Protein-Specific Glycan Imaging and Editing. ChemBioChem, https://doi.org/10.1002/cbic.202200778

6. Jing Yang,# Kefan Wang,# Shanyu Zhang, Xiaocui Zheng, Tongxiao Cui, Xian Yang, Yao Liu, Di Lu, Yuqin Wang, Xiao Tian, Panke Zhang, Shuo Hunag,* and Ran Xie* (2023). Site-Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion. Angewandte Chemie International Edition, https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202216115

7.Zhong, Tong, Younan Chen, Xiaomin Yan, Yiran Li, Haiqi Wang, Yihong Zhong, Ke Li et al. A Patching and Coding Lipid Raft-Localized Universal Imaging Platform. Chemical & Biomedical Imaging 2, no. 2 (2023): 135-146.

2022

1. Tongxiao Cui,# Yi Man,# Feifei Wang, Shuyang Bi, Liang Lin,* Ran Xie* (2022). Glycoenzyme Tool Development: Principles, Screening Methods, and Recent Advances. Chinese Journal of Chemistry,  https://doi.org/10.1002/cjoc.202100770

2. Wang, Feifei,# Hao Kong,# Xiangfeng Meng, Xiao Tian, Changjiang Wang, Lei Xu, Xiang Zhang, Lei Wang,* and Ran Xie* (2022). A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules. RSC Chemical Biology, https://doi.org/10.1039/D2CB00072E

3. Anwen Mao, Yan Zhang, Guyu Wang, Tong Zhong, Xinyu Chen, Haiqi Wang, Ran Xie,* Xiaojian Wang, Lin Ding,* Huangxian Ju (2022). Aglycone sterics-selective enzymatic glycan remodeling. iScience, https://doi.org/10.1016/j.isci.2022.104578

4. Minglun Liu, Yuncong Chen,* Yan Guo, Hao Yuan, Tongxiao Cui, Shankun Yao, Suxing Jin, huanhuan Fan, Chengjun Wang, Ran Xie, Weijing He,* Zijian Guo* (2022) Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy. Nature Communications,  https://doi.org/10.1038/s41467-022-29872-7

Prior to NJU

1. Ran Xie, Rebecca J. Taylor and Daniel Kahne (2018). Outer Membrane Translocon Communicates with Inner Membrane ATPase To Stop Lipopolysaccharide Transport. J. Am. Chem. Soc., 140 (40), 12691-12694.

2. Yuting Sun, Senlian Hong, Ran Xie, Rongbing Huang, Ruoxing Lei, Bo Cheng, Deen Sun, Yifei Du, Corwin Nycholat, James Paulson and Xing Chen (2018). Mechanistic Investigation and Multiplexing of Liposome-Assisted Metabolic Glycan Labeling. J. Am. Chem. Soc., 140 (10), 3592–3602.

3. David J. Sherman*, Ran Xie*, Rebecca J. Taylor*, Alex H. George*, Suguru Okuda*, Peter J. Foster*, Daniel J. Needleman and Daniel Kahne (2018). Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge. Science. 359 (6377), 798-801. *Authors contributed equally.

4. Yifei Du, Ran Xie, Yuting Sun, Xinqi Fan and Xing Chen (2017). Liposome-assisted metabolic glycan labeling with cell and tissue selectivity. Meth. in Enzymol., 598:321-353.

5. Eileen Moison, Ran Xie, Ge Zhang, Matthew D. Lebar, Timothy C. Meredith, and Daniel Kahne (2017). A Fluorescent probe distinguishes between inhibition of early and late steps of lipopolysaccharide biogenesis in whole cells. ACS Chem. Biol.,12 (4), 928-932.

6. Gong Zhang, Jie Li, Ran Xie, Xinyuan Fan, Yanjun Liu, Siqi Zheng, Yun Ge and Peng Chen (2016). Bioorthogonal chemical activation of kinases in living systems. ACS Cent. Sci., 2(5), 325-331.

7. Ran Xie, Lu Dong, Rui Hua, Chen Zhang and Xing Chen (2016). In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy. Proc. Natl. Acad. Sci. U.S.A., 113(19), 5173-5178.

8. Bo Cheng, Ran Xie, Lu Dong and Xing Chen (2016). Metabolic remodeling of cell-surface sialic acids: principles, applications, and recent advances. ChemBioChem, 17(1), 11-27.

9. Liang Lin, Ling Liu, Ran Xie, Bing Zhao, Wei Lin, Minlong Shi, Ye-Guang Chen, Timothy A. Springer and Xing Chen (2015). Carbon nanotube-assisted optical activation of TGF-β signaling by near-infrared light. Nat. Nanotech., 10, 465-471.

10. Ran Xie, Lu Dong, Rongbing Huang, Senlian Hong, Ruoxing Lei and Xing Chen (2014). Targeted imaging of tumor-associated glycans in living animals. Angew. Chem. Int. Ed., 53(51), 14082-14086.

11. Ran Xie, Senlian Hong and Xing Chen. (2013). Cell-selective metabolic labeling of biomolecules with bioorthogonal functionalities. Curr. Opin. Chem. Biol. 17(5), 747-752.

12. Ran Xie, Senlian Hong, Lianshun Feng, Jie Rong and Xing Chen. (2012). Cell-selective metabolic glycan labeling based on ligand-targeted liposomes. J. Am. Chem. Soc., 134(24), 9914-9917.

13. Sara H. Rouhanifard^*, Ran Xie^*, Guoxin Zhang, Xiaoming Sun, Xing Chen and Peng Wu. (2012). Detection and isolation of dendritic cells using Lewis X-functionalized magnetic nanoparticles. Biomacromolecules, 13(10), 3039-3045. *Authors contributed equally.

14. Li Lin, Ran Xie, Shaoai Xie, Nenghu Fang. (2010). Separation and quantitative analysis of microcystins in water using micro-column HILIC. Research and Exploration in Laboratory, 29(11), 203-205.

15. Ran Xie, Ziming Zhao, Xiaorong Dang. (2010). Progress in research of polyurethane/carbon nanotubes composites. China Synthetic Rubber Industry, 33(3), 238-243.

著作：

《中国学科发展战略·化学生物学》，科学出版社，ISBN 978-7-03-043399-2

有待更新，几点想说的话：

1）AI时代让每个人（包括我）变得更加蠢笨和趋利避害，起高楼，宴宾客，然后呢？

2）传统的教学模式有点过时了，所以找自己，做自己，相信自己的，就是最好的学生。

3）PhD不是permanent head damage, 而是成为一个thinker，学习用一种方法论判断价值取向，让自己快乐。

4）唯美食与爱不可辜负，好好吃饭，平安喜乐，了却生死无大事，如何面对都是对。

有待更新

请微信搜索“谢然课题组”关注最新糖科学前沿文献推送和趣味历史、

课题组基本信息、成员介绍、人才招聘等。谢谢！