Wang Shaozhong
Phone Number:
Office Address: E507
E-mail: wangsz@nju.edu.cn
Group Page:
Personal Profile

Shaozhong Wang was born in P. R. China, in 1975. He received his Bsc degree in Chemistry from Nanjing University in 1996 and his PhD in 2002 from the same university working with Prof. Yuefei Hu. He started his independent academic career at Nanjing University and was promoted to an associate professor in 2005, and to a Ph. D. mentor in 2016. From September 2005 to August 2006, he carried out post-doctoral research with Prof. Liming Zhang at University of Nevada, Reno. He has published 55 academic papers as the first author and corresponding author, and presided over NSFC projects and NSF projects of Jiangsu province.

Show All
Work Experience

From Sept. 2002 to May 2005    Assistant professor in School of Chemistry, Nanjing University, China

From Jun 2005 to now                Associate professor in School of Chemistry, Nanjing University, China

From Sept. to Aug. 2006            Postdoctoral fellow in Department of Chemistry, University of Nevada, Reno, USA 

From Jun 2016 to now                Ph. D. mentor in School of Chemistry, Nanjing University, China





Show All
Research

1. Asymmetric Transformations of Alkynes


2. Total Synthesis of Hybrids of Alkaloids and Iridoids




Publications

55.  Yuan, X.; Wang, S.* Indium-Catalyzed Synthesis of 4-Alkynyl-2-quinolones Accompanied by Alkyne Migration. Org. Lett. 202628, 1270-1275. 

54. Xu, Z.-W.; Wang, S.*Palladium-Catalyzed Enantioselective Hydroamination of Alkoxyallenes with 2‑Pyridones. J. Org. Chem. 202590, 18079-18091. 

53.  Yuan, X.; Yang, J.; Wang, S.* Sc(III)-Catalyzed Carbonyl-Yne Reaction for the Diastereoselective Allene Synthesis: A Concerted Asynchronous Mechanism. Org. Lett. 202527, 11169-11174.

52. Xu, Z.-W.; Wang, S.* Noncovalent Interactions in the Palladium-Catalyzed Diastereo- and Enantioselective Hydroalkylations with 2-Acylimidazoles. Org. Lett. 202527, 8817-8822.

51. Xue, Y.; Wang, S.* C−H Arylation of Aminoquinones through Electrochemical Denitrogenative Coupling. J. Org. Chem. 202590, 2553-2557. 

50.  Su, Z.; Wang, S.* Multicomponent Synthesis of 3(2H)-Furanones Initiated by Copper(II)-Catalyzed Alkyne-Carbonyl Cross Metathesis. Chem. Eur. J. 2024e202401999.

49. Xue, Y.; Wang, S*. Generation of Carbonyl Compounds from Oximes through Electrooxidative Deoximation. J. Org. Chem. 2024894199-4204.

48. Qi, Z.; Wang, S*. Construction of Cyclic Nitrones Enabled by Photodriven and Gold-Catalyzed 1,3-Azaprotio Transfer of Allenyloximes. J. Org. Chem. 202388, 15395-15403.

47. Xu, Z.-W.; Wang, S.* Access to Chiral O,O-Acetals Enabled by Palladium-Catalyzed Asymmetric Addition of Oximes to Alkoxyallenes. Chem. Eur. J. 202329, e202301883.

46. Su, Z.; Amin, P. M.; Wang, S.* Gold(I)-Catalyzed Ring-Closing Alkyne-Carbonyl Metathesis for the Synthesis of Butenolides. Chem. Eur. J. 202329,e202302044.

45. Su, Z.; Wang, S.* Construction of 4-Acyl-2-quinolones through Sc(OTf)3-Catalyzed Ring-Closing Alkyne-Carbonyl Metathesis. J. Org. Chem. 2022, 87,16873-16881.

44. Jiang, D.; Chen, Y.; Wang, S.* Total Synthesis of Marine Alkaloids Cystodytins A−K. J. Org. Chem. 202287, 11063-11072.

43.  Amin, P. M.; Su, Z.; Wang, S.* Gold-Catalyzed Cycloisomerization of Propargyl Pyruvates Enabling Unified Access to Tricladolides C and D, Chaetomellic Anhydride A and Tyromycin A. J. Org. Chem. 202186, 15318-15325.

42. Jiang, D.; Wang, S.* Oxidative Cyclization of Kynuramine and Ynones Enabling Collective Syntheses of Pyridoacridine Alkaloids. J. Org. Chem. 202186, 15532-15543.

41.  Qi, Z.; Wang, S.* Chemodivergent Synthesis of Oxazoles and Oxime Ethers Initiated by Selective C-N/C-O Fromation of Oximes and Diazo Esters. Org. Lett. 202123, 8549-8553.

40. Qiao, J.; Liu, H.*; Wang, S.* Access to Indole-Annulated Medium-Sized Lactams through Protonation/Deuteration-Induced Ring-Opening of Spiroindolines. ACS Omega 20216, 25049-25061.

39. Qiao, J.; Chang, W.; Zhao, W.; Liang, Y.; Wang, S.* Kinetic Resolution of Spiroindolines through Ir-Catalyzed Asymmetric Allylative Ring-Opening Reaction. Org. Lett. 202123, 6664-6668.

38. Amin, P. M.; Cui, Q.; Wang, S.*; Yu, Z.-X.*, (Z)-gama-Alkylidenebutenolide Synthesis through Au(I)-Catalyzed 1,3-Acyloxy Migration and the Carbonyl-Ene Reaction. Org. Lett. 202123, 5669-5673. 

37. Qi, Z.; Wang, S.* Copper-Catalyzed beta-Lactam Formation Initiated by 1,3-Azaprotio Transfer of Oximes and Methyl Propiolate. Org. Lett. 202123, 5777-5781.

36. Qiao, J.; Zhao, W.; Liang, Y.*; Yao, Z.-J.; Wang, S.* DiastereoselectiveAccess to Tetracyclic Eight-Membered Lactams through a Dearomative Heck Reaction and an Alkylative Ring-Opening Driven by the Photoexcited Spiroindolines. Chem. Eur. J. 202127, 6308-6314. 

35. Cai, Y.; Zhao, W.; S. Wang, S.*; Liang, Y.; Yao, Z.-J. Access to Functionalized E-Allylsilanes and E-Alkenylsilanes through Visible-Light-Driven Radical Hydrosilylation of Mono- and Disubstituted Allenes. Org. Lett. 201921, 9836-9840.

34. Cui, W.-C.; Zhao, W.; Gao, M.; Liu, W.; Wang, S.*; Liang, Y.*; Yao, Z.-J.* Diastereoselective Synthesis of Polysubstituted Piperidinesthrough Visible-Light-Driven Silylative Cyclization of Aza-1,6-Dienes: Experimental and DFT Studies. Chem. Eur. J. 201942, 16506-16510. 

33. Wang, C.; Cui, Q.; Zhang, Z.; Yao, Z.-J.; Wang, S.*; Yu, Z.-X.* Divergent Synthesis of Oxa-Cyclic Nitrones through Gold(I)-Catalyzed 1,3-Azaprotio Transfer of Propargylic a-Ketocarboxylate Oximes: Experimental and DFT Studies. Chem. Eur. J. 2019, 42, 9821-9826.

32. Zhu, J.; Cui, W.-C.; Wang, S.*; Yao, Z.-J.* Visible Light-Driven Radical trans-Hydrosilylation of Electron-Neutral and –Rich Alkenes with Tertiary and Secondary Hydrosilanes. J. Org. Chem. 201883, 14600-14609.  

31. Zhu, J.; Cui, W.-C.; Wang, S.*; Yao, Z.-J.* Radical Hydrosilylation of Alkynes Catalyzed by Eosin Y and Thiol under Visible Light Irradiation. Org. Lett. 201820, 3174-3178.

30. Wang, S.* Alkaloid Synthesis via Gold-Catalyzed Carbon-Carbon Bond Formation Using Enamine-type   Nucleophile. Isr. J. Chem. 201858, 557-567.

29. Wang, S.* Transition metal-catalyzed reactions of propargylic carboxylates via an initial 1,2-acyloxy   migration. Tetrahedron Lett. 201859, 1317-1327.

28. Zhu, J.; Yuan, Y.; Wang, S.*; Yao, Z.-J.* Synthesis of 2,3-Dialkylated Tartaric Acid Esters via Visible Light   Photoredox-Catalyzed Reductive Dimerization of alfa-Ketoesters. ACS Omega 2017, 2, 4665-4677.

27.  Chang, L.; Guo, T.; Wang, Z.; Wang, S.*; Yao, Z.-J. Azepinoindole Synthesis via a N-Bromosuccinimide-Induced Cycloisomerization of Enaminoester/Enaminone. J. Org. Chem. 201782, 1567-1574.

26. Zhang, L.; Wang, Y.; Yao, Z.-J.; Wang, S.*; Yu, Z.-X.* Kinetic or Dynamic Control on a   Bifurcating   Potential  Energy Surface? An Experimental and DFT Study of Gold-Catalyzed Ring-   Expansion and   Spirocyclization of 2-Propargyl-beta-tetahydrocarbolines. J. Am. Chem. Soc. 2015137, 13290-13300.

25.  Zhang, L.; Chang, L.; Hu, H.; Wang, H.; Yao, Z.-J.; Wang, S.* Azocinoindole Synthesis by a Gold(I)-  Catalyzed Ring Expansion of 2-Propargyl-beta-Tetrahydrocarboline. Chem. Eur. J. 201420, 2925-2932.

24. Yin, H.; Shan, N.; Wang, S.*; Yao, Z.-J. Total Synthesis of Ascididemin-Type Alkaloids Using   Alkyne  Building Blocks. J. Org. Chem. 201479, 9748-9753.

23. Hou, Q.; Zhang, Z.; Kong, F.; Wang, S.*; Wang, H.; Yao, Z.-J. Assembly of fused indenes via Au(I)- catalyzed C1–C5 cyclization of enediynes bearing an internal nucleophile. Chem. Commun. 201349, 695-697.

22.  Xu, M.; Xu, K.; Wang, S.*; Yao, Z.-J. Assembly of indolo[1,2-c] quinazolines using ZnBr2-promoted domino hydroamination–cyclization. Tetrahedron Lett. 201354, 4675-4678.

21.  Zhang, Z.; Chang, L.; Wang, S.*; Wang, H.; Yao, Z.-J. Synthesis of 2-Vinyl-2H-benzotriazoles via NIS-Promoted Regio/ Stereoselective Addition of 1H-Benzotriazole to Alkynes. RSC Advance 20133, 18445-18452.

20.  Yin, H.; Kong, F.; Wang, S.*; Yao, Z.-J. Assembly of Pentacyclic Pyrido[4,3,2-mn]acridin-8-ones via a   Domino Reaction  Initiated by Au(I)-Catalyzed 6-endo-dig Cycloisomerization of N-Propargylamino   quinones. Tetrahedron Lett. 201253, 7078-7082.

19.  Fei, N.; Yin, H.; Wang, S.*; Wang, H.; Yao, Z.-J. CuCl2-Promoted 6-endo-dig Chlorocyclization and Oxidative Aromatization Cascade: Efficient Construction of 1-Azaanthraquinones from N-Propargylaminoquinones. Org. Lett. 201113, 4208-4211.

18.  Xu, M.; Hou, Q.; Wang, S.*; Wang, H.; Yao, Z.-J. Facile Assembly of 11H-Indolo[3,2-c]quinoline by a Two-   step Protocol Involving a Regioselective 6-endo-Cyclization Promoted by the Hendrickson   Rreagent. Synthesis 2011, 626-634.

17. Jiang, C.; Xu, M.; Wang, S.*; Wang, H.; Yao, Z.-J. Azaanthraquinone Assembly from N-Propargylamino-Quinone via a Au(I)-Catalyzed 6-endo-dig Cycloisomerization. J. Org. Chem. 201075, 4323-4325.

16. Fei, N.; Hou, Q.; Wang, S.*; Wang, H.; Yao, Z.-J. Azaanthraquinone Assembly from N-Propargylaminoquinone via Iodine-Induced 6-endo-dig Electrophilic Cyclization. Org. Biomol. Chem. 20108, 4096-4103.

15. Wang, S.; Zhang, G.; Zhang, L.* Gold-Catalyzed Reaction of Propargylic Carboxylates via an Initial 3,3-Rearrangement. Synlett 2010, 692-706.

14. Wu, M.; Wang, S.* An Alternative to Pictet-Gams Reaction Triggered by Hendrickson Reagent: Isoquinolines and beta-Carbolines from Amides. Synthesis 2010, 587-592. 

13. Jiang, C.; Wang, S.* Gold(III)-Catalyzed 1,4-Nucleophilic Addition: Facile Approach to Prepare 2-Amino-1,4-Naphthalenedione and 6-Amino-5,8-quinolinedione derivatives. Synlett 2009, 1099-1102.

12. Li, S.; Wang, S.* FeCl3-Promoted [3+3] Cycloaddition: Efficient Preparation of 1,2-Dihydro-2-Oxo-3-Pyridinecarboxylate and 1,2-Dihydro-2-Oxo-Pyridinecarboxamide Derivatives. J. Heterocyclic. Chem.2008, 45, 1875-1878.

11. Wang, S.; Zhang, L.*A Gold-catalyzed Unique Cycloisomerization of 1,5-Enynes: Efficient Formation of 1-Carboxycyclohexa-1,4-dienes and Carboxyarenes. J. Am. Chem. Soc. 2006128, 14274-14275.

10. Wang, S.; Zhang, L.* A Highly Efficient Preparative Method of alfa-Ylidene-beta-Diketones via AuIII-Catalyzed Acyl Migration of Propargylic Esters. J. Am. Chem. Soc.2006, 128, 8414-8415.

9.  Zhang, L.*; Wang, S. Efficient Synthesis of Cyclopentenones from Enynyl Acetates via Tandem Au(I)-Catalyzed 3,3-Rearrangement and the Nazarov Reaction. J. Am. Chem. Soc. 2006128, 1442-1443.

8.  Wang, S.; Zhang, L.* Gold-Catalyzed Efficient Formation of Alkenyl Enol Esters/Carbonates from Trimethylsilylmethyl-Substituted Propargyl Esters/Carbonates. Org. Lett. 20068, 4585-4587.

7. Wang, S.*; Tan, T.; Li, J.; Hu, H. Highly Efficient One-Pot Synthesis of 1,2-Dihydro-2-Oxo-3-Pyridinecarboxylate Derivatives by FeCl3-Promoted [3+3] Annulation. Synlett 2005, 2658-2660.

6.  Wang, S.*; Pan, J.; Hu, Y.; Hu, H. FeCl3-Promoted Intramolecular Annulation of d-Keto Nitriles: Facile Approach to Prepare 3-Acetamido-2-pyridone Derivatives. Synthesis 2005, 753-756.

5.  Wang, S.; Dong, Y.; Wang, X.; Hu, X.; Liu, J. O.; Hu, Y.* 3-Aryl b-carbolin-1-ones as a new class of potent inhibitors of tumor cell proliferation: synthesis and biological evaluation. Org. Biomol. Chem. 20053, 911-916.

4.  Wang, S.; Cao, L.; Shi, H.; Dong, Y.; Sun, J.; Hu, Y. Preparation of 2-Pyridone-Containing Tricyclic Alkaloid Derivatives as Potential Inhibitors of Tumor Cell Proliferation by Regioselective Intramolecular N- and C- Acylation of 2-Pyridone. Chem. Pharm. Bull. 200553, 67-71.

3.  Wang, S.; Sun, J.; Yu, G.; Hu, X.; Liu, J. O.; Hu, Y.* CuI catalyzed N-arylation of amide as a key step for the preparation of 3-aryl b-carbolin-1-ones. Org. Biomol. Chem. 20042, 1573-1574.

2. Yu, G.; Wang, S.; Wang, K.; Hu, Y.*; Hu, H. A Novel Approach to 1,2-Dihydro-2-Oxo-3-Pyridinecarboxylic Ester via Aromatization Induced by Deamidation. Synthesis 2004, 1021-1028.

1.  Wang, S.; Yu, G.; Lu, J.; Xiao, K.; Hu, Y.*; Hu, H. A Regioselective Tandem Reaction between Chalcones and 2-Acetamidoacetamide Promoted by Cs2CO3 for the Preparation of 3-Unsubstituted 2-Pyridones. Synthesis 2003, 487-490.  




Course Name, Time and Place

《Organic Chemistry》(for undergraduates major in Chemistry)

Syllabus, Examination Requirements
Teaching Resources
Group