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个人简介
王少仲,南京大学副教授,博士生导师。1992年9月至2002年6月在南京大学化学学院学习;先后获得理学学士(1996)、硕士(1999)和博士(2003)学位。2002年7月任职于南京大学化学学院,2005年6月受聘为副教授。2005年9月至2006年9月赴美国内华达州立大学雷诺分校从事博士后研究。2016年6月受聘为博士生导师。以第一作者和通讯作者身份发表学术论文55篇。先后主持国家自然科学基金项目和江苏省自然科学基金项目。 展示全部
工作经历
2002年9月-2005年5月 南京大学化学学院,讲师 2005年6月-至今 南京大学化学学院,副教授 2005年9月-2006年9月: 美国内华达州立大学里诺分校化学系,博士后 2016年6月-至今 南京大学化学学院,博士生导师 展示全部
研究方向
1. 炔烃的不对称转化 2. 生物碱与环烯醚萜杂合体的全合成 学术成果
55. Yuan, X.; Wang, S.* Indium-Catalyzed Synthesis of 4-Alkynyl-2-quinolones Accompanied by Alkyne Migration. Org. Lett.2026, 28, 1270-1275. 54. Xu, Z.-W.; Wang, S.*Palladium-Catalyzed Enantioselective Hydroamination of Alkoxyallenes with 2‑Pyridones. J. Org. Chem. 2025, 90, 18079-18091. 53. Yuan, X.; Yang, J.; Wang, S.* Sc(III)-Catalyzed Carbonyl-Yne Reaction for the Diastereoselective Allene Synthesis: A Concerted Asynchronous Mechanism. Org. Lett. 2025, 27, 11169-11174. 52. Xu, Z.-W.; Wang, S.* Noncovalent Interactions in the Palladium-Catalyzed Diastereo- and Enantioselective Hydroalkylations with 2-Acylimidazoles. Org. Lett. 2025, 27, 8817-8822. 51. Xue, Y.; Wang, S.* C−H Arylation of Aminoquinones through Electrochemical Denitrogenative Coupling. J. Org. Chem. 2025, 90, 2553-2557. 50. Su, Z.; Wang, S.* Multicomponent Synthesis of 3(2H)-Furanones Initiated by Copper(II)-Catalyzed Alkyne-Carbonyl Cross Metathesis. Chem. Eur. J. 2024, e202401999. 49. Xue, Y.; Wang, S*. Generation of Carbonyl Compounds from Oximes through Electrooxidative Deoximation. J. Org. Chem. 2024, 89, 4199-4204. 48. Qi, Z.; Wang, S*. Construction of Cyclic Nitrones Enabled by Photodriven and Gold-Catalyzed 1,3-Azaprotio Transfer of Allenyloximes. J. Org. Chem. 2023, 88, 15395-15403. 47. Xu, Z.-W.; Wang, S.* Access to Chiral O,O-Acetals Enabled by Palladium-Catalyzed Asymmetric Addition of Oximes to Alkoxyallenes. Chem. Eur. J. 2023, 29, e202301883. 46. Su, Z.; Amin, P. M.; Wang, S.* Gold(I)-Catalyzed Ring-Closing Alkyne-Carbonyl Metathesis for the Synthesis of Butenolides. Chem. Eur. J. 2023, 29,e202302044. 45. Su, Z.; Wang, S.* Construction of 4-Acyl-2-quinolones through Sc(OTf)3-Catalyzed Ring-Closing Alkyne-Carbonyl Metathesis. J. Org. Chem. 2022, 87,16873-16881. 44. Jiang, D.; Chen, Y.; Wang, S.* Total Synthesis of Marine Alkaloids Cystodytins A−K. J. Org. Chem. 2022, 87, 11063-11072. 43. Amin, P. M.; Su, Z.; Wang, S.* Gold-Catalyzed Cycloisomerization of Propargyl Pyruvates Enabling Unified Access to Tricladolides C and D, Chaetomellic Anhydride A and Tyromycin A. J. Org. Chem. 2021, 86, 15318-15325. 42. Jiang, D.; Wang, S.* Oxidative Cyclization of Kynuramine and Ynones Enabling Collective Syntheses of Pyridoacridine Alkaloids. J. Org. Chem. 2021, 86, 15532-15543. 41. Qi, Z.; Wang, S.* Chemodivergent Synthesis of Oxazoles and Oxime Ethers Initiated by Selective C-N/C-O Fromation of Oximes and Diazo Esters. Org. Lett. 2021, 23, 8549-8553. 40. Qiao, J.; Liu, H.*; Wang, S.* Access to Indole-Annulated Medium-Sized Lactams through Protonation/Deuteration-Induced Ring-Opening of Spiroindolines. ACS Omega 2021, 6, 25049-25061. 39. Qiao, J.; Chang, W.; Zhao, W.; Liang, Y.; Wang, S.* Kinetic Resolution of Spiroindolines through Ir-Catalyzed Asymmetric Allylative Ring-Opening Reaction. Org. Lett. 2021, 23, 6664-6668. 38. Amin, P. M.; Cui, Q.; Wang, S.*; Yu, Z.-X.*, (Z)-gama-Alkylidenebutenolide Synthesis through Au(I)-Catalyzed 1,3-Acyloxy Migration and the Carbonyl-Ene Reaction. Org. Lett. 2021, 23, 5669-5673. 37. Qi, Z.; Wang, S.* Copper-Catalyzed beta-Lactam Formation Initiated by 1,3-Azaprotio Transfer of Oximes and Methyl Propiolate. Org. Lett. 2021, 23, 5777-5781. 36. Qiao, J.; Zhao, W.; Liang, Y.*; Yao, Z.-J.; Wang, S.* DiastereoselectiveAccess to Tetracyclic Eight-Membered Lactams through a Dearomative Heck Reaction and an Alkylative Ring-Opening Driven by the Photoexcited Spiroindolines. Chem. Eur. J. 2021, 27, 6308-6314. 35. Cai, Y.; Zhao, W.; S. Wang, S.*; Liang, Y.; Yao, Z.-J. Access to Functionalized E-Allylsilanes and E-Alkenylsilanes through Visible-Light-Driven Radical Hydrosilylation of Mono- and Disubstituted Allenes. Org. Lett. 2019, 21, 9836-9840. 34. Cui, W.-C.; Zhao, W.; Gao, M.; Liu, W.; Wang, S.*; Liang, Y.*; Yao, Z.-J.* Diastereoselective Synthesis of Polysubstituted Piperidinesthrough Visible-Light-Driven Silylative Cyclization of Aza-1,6-Dienes: Experimental and DFT Studies. Chem. Eur. J. 2019, 42, 16506-16510. 33. Wang, C.; Cui, Q.; Zhang, Z.; Yao, Z.-J.; Wang, S.*; Yu, Z.-X.* Divergent Synthesis of Oxa-Cyclic Nitrones through Gold(I)-Catalyzed 1,3-Azaprotio Transfer of Propargylic a-Ketocarboxylate Oximes: Experimental and DFT Studies. Chem. Eur. J. 2019, 42, 9821-9826. 32. Zhu, J.; Cui, W.-C.; Wang, S.*; Yao, Z.-J.* Visible Light-Driven Radical trans-Hydrosilylation of Electron-Neutral and –Rich Alkenes with Tertiary and Secondary Hydrosilanes. J. Org. Chem. 2018, 83, 14600-14609. 31. Zhu, J.; Cui, W.-C.; Wang, S.*; Yao, Z.-J.* Radical Hydrosilylation of Alkynes Catalyzed by Eosin Y and Thiol under Visible Light Irradiation. Org. Lett. 2018, 20, 3174-3178. 30. Wang, S.* Alkaloid Synthesis via Gold-Catalyzed Carbon-Carbon Bond Formation Using Enamine-type Nucleophile. Isr. J. Chem. 2018, 58, 557-567. 29. Wang, S.* Transition metal-catalyzed reactions of propargylic carboxylates via an initial 1,2-acyloxy migration. Tetrahedron Lett. 2018, 59, 1317-1327. 28. Zhu, J.; Yuan, Y.; Wang, S.*; Yao, Z.-J.* Synthesis of 2,3-Dialkylated Tartaric Acid Esters via Visible Light Photoredox-Catalyzed Reductive Dimerization of alfa-Ketoesters. ACS Omega 2017, 2, 4665-4677. 27. Chang, L.; Guo, T.; Wang, Z.; Wang, S.*; Yao, Z.-J. Azepinoindole Synthesis via a N-Bromosuccinimide-Induced Cycloisomerization of Enaminoester/Enaminone. J. Org. Chem. 2017, 82, 1567-1574. 26. Zhang, L.; Wang, Y.; Yao, Z.-J.; Wang, S.*; Yu, Z.-X.* Kinetic or Dynamic Control on a Bifurcating Potential Energy Surface? An Experimental and DFT Study of Gold-Catalyzed Ring- Expansion and Spirocyclization of 2-Propargyl-beta-tetahydrocarbolines. J. Am. Chem. Soc. 2015, 137, 13290-13300. 25. Zhang, L.; Chang, L.; Hu, H.; Wang, H.; Yao, Z.-J.; Wang, S.* Azocinoindole Synthesis by a Gold(I)- Catalyzed Ring Expansion of 2-Propargyl-beta-Tetrahydrocarboline. Chem. Eur. J. 2014, 20, 2925-2932. 24. Yin, H.; Shan, N.; Wang, S.*; Yao, Z.-J. Total Synthesis of Ascididemin-Type Alkaloids Using Alkyne Building Blocks. J. Org. Chem. 2014, 79, 9748-9753. 23. Hou, Q.; Zhang, Z.; Kong, F.; Wang, S.*; Wang, H.; Yao, Z.-J. Assembly of fused indenes via Au(I)- catalyzed C1–C5 cyclization of enediynes bearing an internal nucleophile. Chem. Commun. 2013, 49, 695-697. 22. Xu, M.; Xu, K.; Wang, S.*; Yao, Z.-J. Assembly of indolo[1,2-c] quinazolines using ZnBr2-promoted domino hydroamination–cyclization. Tetrahedron Lett. 2013, 54, 4675-4678. 21. Zhang, Z.; Chang, L.; Wang, S.*; Wang, H.; Yao, Z.-J. Synthesis of 2-Vinyl-2H-benzotriazoles via NIS-Promoted Regio/ Stereoselective Addition of 1H-Benzotriazole to Alkynes. RSC Advance 2013, 3, 18445-18452. 20. Yin, H.; Kong, F.; Wang, S.*; Yao, Z.-J. Assembly of Pentacyclic Pyrido[4,3,2-mn]acridin-8-ones via a Domino Reaction Initiated by Au(I)-Catalyzed 6-endo-dig Cycloisomerization of N-Propargylamino quinones. Tetrahedron Lett. 2012, 53, 7078-7082. 19. Fei, N.; Yin, H.; Wang, S.*; Wang, H.; Yao, Z.-J. CuCl2-Promoted 6-endo-dig Chlorocyclization and Oxidative Aromatization Cascade: Efficient Construction of 1-Azaanthraquinones from N-Propargylaminoquinones. Org. Lett. 2011, 13, 4208-4211. 18. Xu, M.; Hou, Q.; Wang, S.*; Wang, H.; Yao, Z.-J. Facile Assembly of 11H-Indolo[3,2-c]quinoline by a Two- step Protocol Involving a Regioselective 6-endo-Cyclization Promoted by the Hendrickson Rreagent. Synthesis 2011, 626-634. 17. Jiang, C.; Xu, M.; Wang, S.*; Wang, H.; Yao, Z.-J. Azaanthraquinone Assembly from N-Propargylamino-Quinone via a Au(I)-Catalyzed 6-endo-dig Cycloisomerization. J. Org. Chem. 2010, 75, 4323-4325. 16. Fei, N.; Hou, Q.; Wang, S.*; Wang, H.; Yao, Z.-J. Azaanthraquinone Assembly from N-Propargylaminoquinone via Iodine-Induced 6-endo-dig Electrophilic Cyclization. Org. Biomol. Chem. 2010, 8, 4096-4103. 15. Wang, S.; Zhang, G.; Zhang, L.* Gold-Catalyzed Reaction of Propargylic Carboxylates via an Initial 3,3-Rearrangement. Synlett 2010, 692-706. 14. Wu, M.; Wang, S.* An Alternative to Pictet-Gams Reaction Triggered by Hendrickson Reagent: Isoquinolines and beta-Carbolines from Amides. Synthesis 2010, 587-592. 13. Jiang, C.; Wang, S.* Gold(III)-Catalyzed 1,4-Nucleophilic Addition: Facile Approach to Prepare 2-Amino-1,4-Naphthalenedione and 6-Amino-5,8-quinolinedione derivatives. Synlett 2009, 1099-1102. 12. Li, S.; Wang, S.* FeCl3-Promoted [3+3] Cycloaddition: Efficient Preparation of 1,2-Dihydro-2-Oxo-3-Pyridinecarboxylate and 1,2-Dihydro-2-Oxo-Pyridinecarboxamide Derivatives. J. Heterocyclic. Chem.2008, 45, 1875-1878. 11. Wang, S.; Zhang, L.*A Gold-catalyzed Unique Cycloisomerization of 1,5-Enynes: Efficient Formation of 1-Carboxycyclohexa-1,4-dienes and Carboxyarenes. J. Am. Chem. Soc. 2006, 128, 14274-14275. 10. Wang, S.; Zhang, L.* A Highly Efficient Preparative Method of alfa-Ylidene-beta-Diketones via AuIII-Catalyzed Acyl Migration of Propargylic Esters. J. Am. Chem. Soc.2006, 128, 8414-8415. 9. Zhang, L.*; Wang, S. Efficient Synthesis of Cyclopentenones from Enynyl Acetates via Tandem Au(I)-Catalyzed 3,3-Rearrangement and the Nazarov Reaction. J. Am. Chem. Soc. 2006, 128, 1442-1443. 8. Wang, S.; Zhang, L.* Gold-Catalyzed Efficient Formation of Alkenyl Enol Esters/Carbonates from Trimethylsilylmethyl-Substituted Propargyl Esters/Carbonates. Org. Lett. 2006, 8, 4585-4587. 7. Wang, S.*; Tan, T.; Li, J.; Hu, H. Highly Efficient One-Pot Synthesis of 1,2-Dihydro-2-Oxo-3-Pyridinecarboxylate Derivatives by FeCl3-Promoted [3+3] Annulation. Synlett 2005, 2658-2660. 6. Wang, S.*; Pan, J.; Hu, Y.; Hu, H. FeCl3-Promoted Intramolecular Annulation of d-Keto Nitriles: Facile Approach to Prepare 3-Acetamido-2-pyridone Derivatives. Synthesis 2005, 753-756. 5. Wang, S.; Dong, Y.; Wang, X.; Hu, X.; Liu, J. O.; Hu, Y.* 3-Aryl b-carbolin-1-ones as a new class of potent inhibitors of tumor cell proliferation: synthesis and biological evaluation. Org. Biomol. Chem. 2005, 3, 911-916. 4. Wang, S.; Cao, L.; Shi, H.; Dong, Y.; Sun, J.; Hu, Y. Preparation of 2-Pyridone-Containing Tricyclic Alkaloid Derivatives as Potential Inhibitors of Tumor Cell Proliferation by Regioselective Intramolecular N- and C- Acylation of 2-Pyridone. Chem. Pharm. Bull. 2005, 53, 67-71. 3. Wang, S.; Sun, J.; Yu, G.; Hu, X.; Liu, J. O.; Hu, Y.* CuI catalyzed N-arylation of amide as a key step for the preparation of 3-aryl b-carbolin-1-ones. Org. Biomol. Chem. 2004, 2, 1573-1574. 2. Yu, G.; Wang, S.; Wang, K.; Hu, Y.*; Hu, H. A Novel Approach to 1,2-Dihydro-2-Oxo-3-Pyridinecarboxylic Ester via Aromatization Induced by Deamidation. Synthesis 2004, 1021-1028. 1. Wang, S.; Yu, G.; Lu, J.; Xiao, K.; Hu, Y.*; Hu, H. A Regioselective Tandem Reaction between Chalcones and 2-Acetamidoacetamide Promoted by Cs2CO3 for the Preparation of 3-Unsubstituted 2-Pyridones. Synthesis 2003, 487-490. 课程名称、上课时间地点
《基础有机化学》(化学专业) 教学大纲、考试要求
教学资源(上课讲义、参考资料等)
课题组风采
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