1986年生，教授，博士生导师，国家优秀青年基金获得者，国家重点研发计划青年科学家项目首席。2007年获南京大学理学学士学位，2012年获南京大学理学博士学位，2012年4月留校担任助理研究员。2013-2014年赴斯坦福大学化学系从事访问学者研究 （合作导师：Richard N. Zare）。2015年任副教授，2022年任教授。2016年获国家自然科学基金优秀青年科学基金项目资助。主要研究方向为质谱分析，包括原位电离质谱、纳米标签质谱的方法学开发及其在生命过程、化学过程分子信息动态监测中的应用。在Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、ACS Nano、Chem. Sci.、Anal. Chem.等期刊发表论文70多篇。主持国家重点研发计划青年科学家项目1项，国家自然科学基金面上项目3项，重大研究计划培育项目1项。欢迎对纳米生物技术、质谱分析感兴趣的同学报考我的硕士、博士研究生，同时欢迎本科同学加入我们的研究团队。

2003. 9–2007. 6，南京大学，化学，学士学位

2007. 9–2012. 3，南京大学，化学，博士学位

2012. 4–2015. 3，南京大学，化学系，助理研究员

2013. 12–2015. 1，斯坦福大学，化学系，访问学者

2015. 4–2015. 7，南京大学，化学系，副研究员

2015. 8–2022. 6，南京大学，化学系，副教授

2022. 7至今，南京大学，化学系，教授

主要研究方向为纳米生物分析与质谱分析，包括纳米标签质谱分析、原位质谱分析以及纳米药物递送系统。多年来我们致力于通过纳米探针的合理设计与功能调控，发展生物质谱分析新方法与肿瘤诊疗新策略。开发纳米探针分离介质与信号编码载体，发展了细胞内蛋白酶、激酶、核酸等多元目标物同步质谱监测新方法，以及组织水平药物分子、代谢产物、蛋白酶质谱成像新策略；设计响应性层级结构纳米界面，构筑肿瘤细胞及微环境特征因子刺激-响应性纳米药物载体，提出了靶标特异性的多元药物递送与肿瘤微环境重构新范式。

一、纳米分离介质与信号载体的构筑与质谱分析应用

针对生物过程中多元生物分子同步监测的方法学问题，以功能纳米探针为分离介质和信号载体，发展可用于细胞内多种活性分子同步监测的质谱分析新方法，以及组织层面药物分子、代谢产物、蛋白酶的质谱成像新策略，以期为揭示复杂生物过程中多元生物分子的协同机制并探寻疾病相关生物分子与治疗靶标提供技术方案。

代表性工作：

1. Zhang, X.; Dong, Y.; Wang, Y.; Zhang, Z.; Zhang, X.; Zhu, J.-J.; Tian, Y.; Min, Q.*, Quality Control of Mass-Encoded Nanodevices by Compartmented DNA Origami Frames for Precision Information Coding and Logic Mapping. Angew. Chem. Int. Ed. 2023, e202313446.

2. Zhang, Z.; Xu, H.; Fan, Y.; Zhang, X.; Wang, W.; Zhu, J.-J.; Min, Q.*, Mass Nanotags Mediate Parallel Amplifications on Nanointerfaces for Multiplexed Profiling of RNAs. Nano Lett. 2023,23 (5), 1820-1829.

3. Zhang, X.; Lu, W.; Ma, C.; Wang, T.; Zhu, J.-J.; Zare, R. N.; Min, Q.*, Insights into electrochemiluminescence dynamics by synchronizing real-time electrical, luminescence, and mass spectrometric measurements. Chem. Sci. 2022,13 (21), 6244-6253.

4. Zhang, X.; Wang, W.; Zare, R. N.*; Min, Q.*, Peptide and protein assays using customizable bio-affinity arrays combined with ambient ionization mass spectrometry. Chem. Sci. 2021, 12 (32), 10810-10816.

5. Xu, H.; Huang, X.; Zhang, Z.; Zhang, X.; Min, Q.*; Zhu, J.-J., Protease-responsive mass barcoded nanotranslators for simultaneously quantifying the intracellular activity of cascaded caspases in apoptosis pathways. Chem. Sci. 2020, 11 (20), 5280-5288.

二、智能纳米探针药物载体的开发与生物医学应用

设计构筑基于DNA组装结构、可降解硅基材料的纳米药物载体，以肿瘤组织中异常表达的生物分子作为触发源，开发针对肿瘤细胞特异性响应的蛋白、基因、化疗药物释放系统，监测分子标志物的空间分布以及药物释放进程，以期为肿瘤的精准治疗与监测提供技术手段。

代表性工作：

1. Xu, Z.; Dong, Y.; Ma, N.; Zhu, X.; Zhang, X.; Yin, H.; Chen, S.; Zhu, J.-J.*; Tian, Y.*; Min, Q.*, Confinement in Dual-Chain-Locked DNA Origami Nanocages Programs Marker-Responsive Delivery of CRISPR/Cas9 Ribonucleoproteins. J. Am. Chem. Soc. 2023,145 (49), 26557-26568.

2. Zhang, Q.; Wang, Y.; Wang, W.; Min, Q.*; Zhang, J.-R.*; Zhu, J.-J.*, A Telomerase-Assisted Strategy for Regeneration of DNA Nanomachines in Living Cells. Angew. Chem. Int. Ed. 2023,62 (6), e202213884.

3. Hu, X.; Chi, H.; Fu, X.; Chen, J.; Dong, L.; Jiang, S.; Li, Y.; Chen, J.; Cheng, M.; Min, Q.*; Tian, Y.*; Zhang, P.*, Tunable Multivalent Aptamer-Based DNA Nanostructures to Regulate Multi-Hetero Receptor-Mediated Tumor Recognition. J. Am. Chem. Soc. 2023, in press.

4. Zheng, F.; Meng, T.; Jiang, D.; Sun, J.; Yao, H.; Zhu, J.-J.; Min, Q.*, Nanomediator-Effector Cascade Systems for Amplified Protein Kinase Activity Imaging and Phosphorylation-Induced Drug Release In Vivo. Angew. Chem. Int. Ed. 2021, 60 (39), 21565-21574.

5. Liang, T.; Zhang, B.; Xing, Z.; Dong, Y.; Xu, H.; Chen, X.; Jiang, L.; Zhu, J.-J.; Min, Q.*, Adapting and Remolding: Orchestrating Tumor Microenvironment Normalization with Photodynamic Therapy by Size Transformable Nanoframeworks. Angew. Chem. Int. Ed. 2021, 60 (20), 11464-11473.

41. Hu, X.; Chi, H.; Fu, X.; Chen, J.; Dong, L.; Jiang, S.; Li, Y.; Chen, J.; Cheng, M.; Min, Q.*; Tian, Y.*; Zhang, P.*, Tunable Multivalent Aptamer-Based DNA Nanostructures to Regulate Multi-Hetero Receptor-Mediated Tumor Recognition. J. Am. Chem. Soc. 2024, 146 (4), 2514−2523.

40. Zhang, X.; Dong, Y.; Wang, Y.; Zhang, Z.; Zhang, X.; Zhu, J.-J.; Tian, Y.; Min, Q.*, Quality Control of Mass-Encoded Nanodevices by Compartmented DNA Origami Frames for Precision Information Coding and Logic Mapping. Angew. Chem. Int. Ed. 2024,63, e202313446.

39. Xu, Z.; Dong, Y.; Ma, N.; Zhu, X.; Zhang, X.; Yin, H.; Chen, S.; Zhu, J.-J.*; Tian, Y.*; Min, Q.*, Confinement in Dual-Chain-Locked DNA Origami Nanocages Programs Marker-Responsive Delivery of CRISPR/Cas9 Ribonucleoproteins. J. Am. Chem. Soc. 2023, 145 (49), 26557-26568.

38. Zhang, Q.; Wang, Y.; Wang, W.; Min, Q.*; Zhang, J.-R.*; Zhu, J.-J.*, A Telomerase-Assisted Strategy for Regeneration of DNA Nanomachines in Living Cells. Angew. Chem. Int. Ed. 2023, 62 (6), e202213884.

37. Zhang, Z.; Xu, H.; Fan, Y.; Zhang, X.; Wang, W.; Zhu, J.-J.; Min, Q.*, Mass Nanotags Mediate Parallel Amplifications on Nanointerfaces for Multiplexed Profiling of RNAs. Nano Lett. 2023, 23 (5), 1820-1829.

36. Huang, S.; Song, Y.; Chen, X.*; Min, Q.*; Zhang, J.-R.*; Zhu, J.-J.*, Synergistic Oxidative Damage with Gene Therapy Potentiates Targeted Sterilization of Broad-Spectrum Microorganisms. Adv. Funct. Mater. 2023, 33 (32), 2300145.

35. Gao, D.; Tang, Z.; Chen, X.; Wu, R.; Tian, Y.; Min, Q.; Zhang, J.-R.; Chen, Z.*; Zhu, J.-J.*, Reversible Regulation of Long-Distance Charge Transport in DNA Nanowires by Dynamically Controlling Steric Conformation. Nano Lett. 2023, 23 (10), 4201-4208.

34. Yin, H.; Chu, Y.; Wang, W.; Zhang, Z.; Meng, Z.; Min, Q.*, Mass tag-encoded nanointerfaces for multiplexed mass spectrometric analysis and imaging of biomolecules. Nanoscale 2023, 15 (6), 2529-2540.

33. Du, H.; Liu, L.-X.; Li, P.; Min, Q.*; Guo, S.*; Zhu, W.*, Enriching Reaction Intermediates in Multishell Structured Copper Catalysts for Boosted Propanol Electrosynthesis from Carbon Monoxide. ACS Nano 2023, 17 (9), 8663-8670.

32. Dai, L.; Hu, X.; Ji, M.; Ma, N.; Xing, H.; Zhu, J.-J.; Min, Q.; Tian, Y.*, Programming the morphology of DNA origami crystals by magnesium ion strength. Proc. Natl. Acad. Sci. U. S. A. 2023, 120 (28), e2302142120.

31. Zhang, X.; Lu, W.; Ma, C.; Wang, T.; Zhu, J.-J.; Zare, R. N.; Min, Q.*, Insights into electrochemiluminescence dynamics by synchronizing real-time electrical, luminescence, and mass spectrometric measurements. Chem. Sci. 2022, 13 (21), 6244-6253.

30. Xu, Z.; Huang, Y.; Yin, H.; Zhu, X.; Tian, Y.; Min, Q.*, DNA Origami-Based Protein Manipulation Systems: From Function Regulation to Biological Application. ChemBioChem 2022, 23 (9), e202100597.

29. Xu, H.; Zhang, Z.; Wang, Y.; Zhang, X.; Zhu, J.-J.*; Min, Q.*, Sense and Validate: Fluorophore/Mass Dual-Encoded Nanoprobes for Fluorescence Imaging and MS Quantification of Intracellular Multiple MicroRNAs. Anal. Chem. 2022, 94 (16), 6329-6337.

28. Li, K.; Cai, Y.; Yang, X.; Wang, S.; Teng, C.; Tian, Y.; Min, Q.; Zhu, W.*, H2S Involved Photocatalytic System: A Novel Syngas Production Strategy by Boosting the Photoreduction of CO2 While Recovering Hydrogen from the Environmental Toxicant. Adv. Funct. Mater. 2022, 32 (20), 2113002.

27. Jin, Z.; Liu, M.; Huang, X.; Zhang, X.; Qu, Z.*; Zhu, J.-J.*; Min, Q.*, Top-Down Rational Engineering of Heteroatom-Doped Graphene Quantum Dots for Laser Desorption/Ionization Mass Spectrometry Detection and Imaging of Small Biomolecules. Anal. Chem. 2022, 94 (21), 7609-7618.

26. Jiang, Y.-W.; Tang, W.-J.; Gao, G.; Geng, Y.-Q.; Wu, F.-G.; Min, Q.*; Zhu, J.-J.*, Lipid droplet-hitchhiking probe creates Trojan foam cells for fluorescence/photoacoustic imaging of atherosclerotic plaques. Biosens. Bioelectron. 2022, 216, 114613.

25. Huang, S.; Song, Y.; Yao, H.; Min, Q.; Zhang, J.-R.*; Zhu, J.-J.*, Multistage Photoactivatable Zinc-Responsive Nanodevices for Monitoring and Regulating Dysfunctional Islet β-Cells. Anal. Chem. 2022,94 (17), 6607-6614.

24. Gao, D.; Ma, N.; Yan, X.; Ji, M.; Zhu, J.-J.*; Min, Q.*; Tian, Y.*, Low-entropy lattices engineered through bridged DNA origami frames. Chem. Sci. 2022, 13 (1), 283-289.

23. Du, H.; Liu, L.-X.; Cai, Y.; Wang, Y.; Zhang, J.-R.; Min, Q.; Zhu, W.*, In situ formed N-containing copper nanoparticles: a high-performance catalyst toward carbon monoxide electroreduction to multicarbon products with high faradaic efficiency and current density. Nanoscale 2022, 14 (19), 7262-7268.

22. Dong, Y.; Liu, J.; Lu, X.; Duan, J.; Zhou, L.; Dai, L.; Ji, M.; Ma, N.; Wang, Y.; Wang, P.; Zhu, J.-J.; Min, Q.; Gang, O.; Tian, Y.*, Two-Stage Assembly of Nanoparticle Superlattices with Multiscale Organization. Nano Lett. 2022,22 (9), 3809-3817.

21. Dong, Y.; Jin, Z.; Zhang, X.; Tang, Y.; Tian, Y.*; Zhu, J.-J.*; Min, Q.*, A six-plex switchable DNA origami cipher disk for tandem-in-time cryptography. Chem. Commun. 2022, 58 (41), 6124-6127.

20. Zheng, F.; Meng, T.; Jiang, D.; Sun, J.; Yao, H.; Zhu, J.-J.; Min, Q.*, Nanomediator-Effector Cascade Systems for Amplified Protein Kinase Activity Imaging and Phosphorylation-Induced Drug Release In Vivo. Angew. Chem. Int. Ed. 2021, 60 (39), 21565-21574.

19. Zhang, X.; Wang, W.; Zare, R. N.*; Min, Q.*, Peptide and protein assays using customizable bio-affinity arrays combined with ambient ionization mass spectrometry. Chem. Sci.2021,12 (32), 10810-10816.

18. Xu, H.; Zhang, Z.; Wang, Y.; Lu, W.; Min, Q.*, Engineering of nanomaterials for mass spectrometry analysis of biomolecules. Analyst 2021, 146, 5779-5799.

17. Liang, T.; Zhang, B.; Xing, Z.; Dong, Y.; Xu, H.; Chen, X.; Jiang, L.; Zhu, J.-J.; Min, Q.*, Adapting and Remolding: Orchestrating Tumor Microenvironment Normalization with Photodynamic Therapy by Size Transformable Nanoframeworks. Angew. Chem. Int. Ed. 2021, 60 (20), 11464-11473.

16. Cai, Y.; Fu, J.; Zhou, Y.; Chang, Y.-C.; Min, Q.*; Zhu, J.-J.; Lin, Y.*; Zhu, W.*, Insights on forming N,O-coordinated Cu single-atom catalysts for electrochemical reduction CO2 to methane. Nat. Commun. 2021, 12 (1), 586.

15. Zhang, K.; Lu, F.; Cai, Z.; Song, S.; Jiang, L.; Min, Q.*; Wu, X.*; Zhu, J.-J.*, Plasmonic Modulation of the Upconversion Luminescence Based on Gold Nanorods for Designing a New Strategy of Sensing MicroRNAs. Anal. Chem. 2020, 92 (17), 11795-11801.

14. Xu, H.; Huang, X.; Zhang, Z.; Zhang, X.; Min, Q.*; Zhu, J.-J., Protease-responsive mass barcoded nanotranslators for simultaneously quantifying the intracellular activity of cascaded caspases in apoptosis pathways. Chem. Sci. 2020, 11 (20), 5280-5288.

13. Zheng, F.; Wang, C.; Meng, T.; Zhang, Y.; Zhang, P.; Shen, Q.; Zhang, Y.; Zhang, J.; Li, J.; Min, Q.*; Chen, J.*; Zhu, J.-J.*, Outer-Frame-Degradable Nanovehicles Featuring Near-Infrared Dual Luminescence for in Vivo Tracking of Protein Delivery in Cancer Therapy. ACS Nano 2019, 13 (11), 12577-12590.

12. Yao, Z.; Zhang, B.; Liang, T.; Ding, J.; Min, Q.*; Zhu, J.-J., Promoting Oxidative Stress in Cancer Starvation Therapy by Site-Specific Startup of Hyaluronic Acid-Enveloped Dual-Catalytic Nanoreactors. ACS Appl. Mater. Interfaces 2019, 11 (21), 18995-19005.

11. Xu, H.; Liu, M.; Huang, X.; Min, Q.*; Zhu, J.-J., Multiplexed Quantitative MALDI MS Approach for Assessing Activity and Inhibition of Protein Kinases Based on Postenrichment Dephosphorylation of Phosphopeptides by Metal-Organic Framework-Templated Porous CeO2. Anal. Chem. 2018, 90 (16), 9859-9867.

10. Liang, T.; Yao, Z.; Ding, J.; Min, Q.*; Jiang, L.*; Zhu, J.-J., Cascaded Aptamers-Governed Multistage Drug-Delivery System Based on Biodegradable Envelope-Type Nanovehicle for Targeted Therapy of HER2-Overexpressing Breast Cancer. ACS Appl. Mater. Interfaces 2018, 10 (40), 34050-34059.

9. Ding, J.; Liang, T.; Min, Q.*; Jiang, L.*; Zhu, J.-J. “Stealth and Fully-Laden” Drug Carriers: Self-Assembled Nanogels Encapsulated with Epigallocatechin Gallate and siRNA for Drug-Resistant Breast Cancer Therapy. ACS Appl. Mater. Interfaces 2018, 10 (12), 9938-9948.

8. Zheng, F.; Zhang, P.; Xi, Y.; Huang, K.; Min, Q.*; Zhu, J.-J.* Peptide-mediated core/satellite/shell multifunctional nanovehicles for precise imaging of cathepsin B activity and dual-enzyme controlled drug release. NPG Asia Mater. 2017, 9, e366.

7. Ding, J.; Liang, T.; Zhou, Y.; He, Z.; Min, Q.*; Jiang, L. *; Zhu, J.-J. *, Hyaluronidase-triggered anticancer drug and siRNA delivery from cascaded targeting nanoparticles for drug-resistant breast cancer therapy. Nano Res. 2017, 10 (2), 690-703.

6. Zhang, P.; Wang, C.; Zhao, J.; Xiao, A.; Shen, Q.; Li, L.; Li, J.; Zhang, J.; Min, Q.*; Chen, J.*; Chen, H.-Y.; Zhu, J.-J.*, Near Infrared-Guided Smart Nanocarriers for MicroRNA-Controlled Release of Doxorubicin/siRNA with Intracellular ATP as Fuel. ACS Nano 2016, 10 (3), 3637-3647.

5. Zhang, P.; He, Z.; Wang, C.; Chen, J.; Zhao, J.; Zhu, X.; Li, C.-Z.; Min, Q.*; Zhu, J.-J.*, In Situ Amplification of Intracellular MicroRNA with MNAzyme Nanodevices for Multiplexed Imaging, Logic Operation, and Controlled Drug Release. ACS Nano 2015,9 (1), 789-798.

4. Chen, Z.; Li, J.; Chen, X.; Cao, J.; Zhang, J.; Min, Q.*; Zhu, J.-J.*, Single Gold@Silver Nanoprobes for Real-Time Tracing the Entire Autophagy Process at Single-Cell Level. J. Am. Chem. Soc. 2015, 137 (5), 1903-1908.

3. Chen, X.; Li, S.; Zhang, X.; Min, Q.*; Zhu, J.-J., Weaving a two-dimensional fishing net from titanoniobate nanosheets embedded with Fe3O4 nanocrystals for highly efficient capture and isotope labeling of phosphopeptides. Nanoscale 2015, 7 (13), 5815-5825.

2. Zhang, P.; Cheng, F.; Zhou, R.; Cao, J.; Li, J.; Burda, C.; Min, Q.*; Zhu, J.-J.*, DNA-Hybrid-Gated Multifunctional Mesoporous Silica Nanocarriers for Dual-Targeted and MicroRNA-Responsive Controlled Drug Delivery. Angew. Chem. Int. Ed. 2014, 53 (9), 2371-2375.

1. Li, J.; Wang, W.; Sun, D.; Chen, J.; Zhang, P.-H.; Zhang, J.-R.; Min, Q.*; Zhu, J.-J.*, Aptamer-functionalized silver nanoclusters-mediated cell type-specific siRNA delivery and tracking. Chem. Sci. 2013, 4 (9), 3514-3521.

现代仪器分析  仙2-113  周三上午3-4节（单周），周五上午3-4节（单、双周）