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Personal Profile
2001-2005 B.Sc., Chemistry, Peking University Supervisor: Prof. Jiaxi Xu Thesis: Origin of the Relative Stereoselectivity of the Ketene-Imine [2+2] Cycloaddition Reactions 2005-2010 Ph.D., Peking University Major: Synthetic and Computational Organic Chemistry Supervisor: Prof. Zhi-Xiang Yu Thesis: Studies on Mechanisms of Organic Reactions and Total Synthesis of Natural Product (+)-Asteriscanolide 2010-2011 Research Associate (with Prof. Zhi-Xiang Yu), Peking University 2012-2015 Postdoctoral Scholar (with Prof. K. N. Houk), University of California, Los Angeles 2015- Professor, School of Chemistry and Chemical Engineering, Nanjing University Show All
Work Experience
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Research
Understanding reaction mechanisms at the molecular level through joint forces of computations and experiments; Fundamental principles and controlling factors for the reactivity and selectivity of important chemical transformations; Computation-guided designs of new catalysts, reactions, and synthetic strategies; Applications of computational tools for solving problems in biology and materials science Publications
AvmM Catalyses Macrocyclization through Dehydration/Michael-Type Addition in Alchivemycin A Biosynthesis Diversification of Aryl Sulfonyl Compounds through Ligand-Controlled meta- and para-C–H Borylation Computationally Designed Ligands Enable Tunable Borylation of Remote C–H Bonds in Arenes In Vitro Reconstitution of Cinnamoyl Moiety Reveals Two Distinct Cyclases for Benzene Ring Formation Regio- and Enantioselective Remote Hydroarylation Using a Ligand-Relay Strategy Metal- and Strain-Free Bioorthogonal Cycloaddition of o-Diones with Furan-2(3H)-one as Anionic Cycloaddend para-Selective C–H Borylation of Aromatic Quaternary Ammonium and Phosphonium Salts Lu, S.; Zheng, T.; Ma, J.; Deng, Z.; Qin, S.; Chen, Y.; Liang, Y.* Angewandte Chemie – International Edition 2022, 61, e202201285. Design and Development of a Bioorthogonal, Visualizable and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery System Influence of Water and Enzyme on the Post-Transition State Bifurcation of NgnD-Catalyzed Ambimodal [6+4]/[4+2] Cycloaddition Ternary Catalysis Enabled Three-Component Asymmetric Allylic Alkylation as a Concise Track to Chiral a,a-Disubstituted Ketones A Relay Catalysis Strategy for Enantioselective Nickel-Catalyzed Migratory Hydroarylation Forming Chiral a-Aryl Alkylboronates An NADPH-Dependent Ketoreductase Catalyses the Tetracyclic to Pentacyclic Skeletal Rearrangement in Chartreusin Biosynthesis A [6+4]-Cycloaddition Adduct Is the Biosynthetic Intermediate in Streptoseomycin Biosynthesis Integrated Redox-Active Reagents for Photoinduced Regio- and Stereoselective Fluorocarboborylation Computational Design of Enhanced Enantioselectivity in Chiral Phosphoric Acid-Catalyzed Oxidative Desymmetrization of 1,3-Diol Acetals Metal-Free Oxidative B−N Coupling of nido-Carborane with N-Heterocycles Enzyme-Catalysed [6+4] Cycloadditions in the Biosynthesis of Natural Products Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters Bioorthogonal Cycloadditions: Computational Analysis with the Distortion/Interaction Model and Predictions of Reactivities Type II Anion Relay Chemistry: Conformational Constraints To Achieve Effective [1,5]-Vinyl Brook Rearrangements Course Name, Time and Place
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