梁勇
职务： 博士生导师
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电子邮箱： yongliang@nju.edu.cn
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个人简介

梁勇 教授 博导

2005年获北京大学学士学位；2010年获北京大学理学博士学位

2014年江苏特聘教授，2015年国家级青年人才计划入选者，2017年中国化学会—物理有机化学新人奖，2019年江苏省“双创”团队领军人才，2020年霍英东教育基金会第十七届高等院校青年教师奖，南京大学本科优秀毕业论文特等奖指导教师，南京大学“我最喜爱的研究生生涯导师”，2021年南京大学魅力导师奖，2022年南京大学青年五四奖章

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工作经历

2012-2015，美国加州大学洛杉矶分校，化学与生物化学系，博士后

     2015/11-，南京大学，化学化工学院，教授

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研究方向

    1）计算和实验相结合研究有机化学反应的机理；2）天然产物生物合成中涉及的有机反应和酶催化机制。3）计算机辅助设计用于有机合成的新催化剂和反应；4）计算指导新生物正交试剂的设计与应用。

学术成果


AvmM Catalyses Macrocyclization through Dehydration/Michael-Type Addition in Alchivemycin A Biosynthesis
Zhu, H. J.#; Zhang, B.#; Wei, W.#; Liu, S. H.; Xiang, L.; Zhu, J.; Jiao, R. H.; Igarashi, Y.; Bashiri, G.; Liang, Y.*; Tan, R. X.*; Ge, H. M.* Nature Communications 2022, 13, 4499.

Diversification of Aryl Sulfonyl Compounds through Ligand-Controlled meta- and para-C–H Borylation
Wang, Y.#; Chang, W.#; Qin, S.; Ang, H.; Ma, J.; Lu, S.; Liang, Y.* Angewandte Chemie – International Edition 2022, 61, e202206797.

Computationally Designed Ligands Enable Tunable Borylation of Remote C–H Bonds in Arenes
Chang, W.#; Chen, Y.#; Lu, S.#; Jiao, H.; Wang, Y.; Zheng, T.; Shi, Z.; Han, Y.; Lu, Y.; Wang, Y.; Pan, Y.; Yu, J.-Q.; Houk, K. N.; Liu, F.; Liang, Y.* Chem 2022, 8, 1775.

In Vitro Reconstitution of Cinnamoyl Moiety Reveals Two Distinct Cyclases for Benzene Ring Formation
Shi, J.; Shi, Y.; Li, J. C.; Wei, W.; Chen, Y.; Cheng, P.; Liu, C. L.; Zhang, H.; Wu, R.; Zhang, B.; Jiao, R. H.; Yu, S.; Liang, Y.*; Tan, R. X.*; Ge, H. M.* Journal of the American Chemical Society 2022, 144, 7939.

Regio- and Enantioselective Remote Hydroarylation Using a Ligand-Relay Strategy
He, Y.; Ma, J.; Song, H.; Zhang, Y.; Liang, Y.*; Wang, Y.*; Zhu, S.* Nature Communications 2022, 13, 2471.

Metal- and Strain-Free Bioorthogonal Cycloaddition of o-Diones with Furan-2(3H)-one as Anionic Cycloaddend
Xi, Z.#; Kong, H.#; Chen, Y.; Deng, J.; Xu, W.; Liang, Y.*; Zhang, Y.* Angewandte Chemie – International Edition 2022, 61, e202200239.

para-Selective C–H Borylation of Aromatic Quaternary Ammonium and Phosphonium Salts
Lu, S.; Zheng, T.; Ma, J.; Deng, Z.; Qin, S.; Chen, Y.; Liang, Y.* Angewandte Chemie – International Edition 2022, 61, e202201285.

Design and Development of a Bioorthogonal, Visualizable and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery System
Chen, Y.#; Zhao, R.#; Tang, C.; Zhang, C.; Xu, W.; Wu, L.; Wang, Y.; Ye, D.; Liang, Y.* Angewandte Chemie – International Edition 2022, 61, e202112734.

Influence of Water and Enzyme on the Post-Transition State Bifurcation of NgnD-Catalyzed Ambimodal [6+4]/[4+2] Cycloaddition
Wang, X.#; Zhang, C.#; Jiang, Y.; Wang, W.; Zhou, Y.; Chen, Y.; Zhang, B.; Tan, R. X.; Ge, H. M.*; Yang, Z. J.*; Liang, Y.* Journal of the American Chemical Society 2021, 143, 21003.

Ternary Catalysis Enabled Three-Component Asymmetric Allylic Alkylation as a Concise Track to Chiral a,a-Disubstituted Ketones
Kang, Z.#; Chang, W.#; Tian, X.; Fu, X.; Zhao, W.; Xu, X.*; Liang, Y.*; Hu, W.* Journal of the American Chemical Society 2021, 143, 20818.

A Relay Catalysis Strategy for Enantioselective Nickel-Catalyzed Migratory Hydroarylation Forming Chiral a-Aryl Alkylboronates
Zhang, Y.; Ma, J.; Chen, J.; Meng, L.; Liang, Y.*; Zhu, S.* Chem 2021, 7, 3171.

An NADPH-Dependent Ketoreductase Catalyses the Tetracyclic to Pentacyclic Skeletal Rearrangement in Chartreusin Biosynthesis
Jiao, F. W.#; Wang, Y. S.#; You, X. T.; Wei, W.; Chen, Y.; Yang, C. L.; Guo, Z. K.; Zhang, B.; Liang, Y.*; Tan, R. X.*; Jiao, R. H.*; Ge, H. M.* Angewandte Chemie – International Edition 2021, 60, 26378.

A [6+4]-Cycloaddition Adduct Is the Biosynthetic Intermediate in Streptoseomycin Biosynthesis
Wang, K. B.#; Wang, W.#; Zhang, B.#; Wang, X.; Chen, Y.; Zhu, H. J.; Liang, Y.*; Tan, R. X.*; Ge, H. M.* Nature Communications 2021, 12, 2092.

Integrated Redox-Active Reagents for Photoinduced Regio- and Stereoselective Fluorocarboborylation
Zhang, W.; Zou, Z.; Zhao, W.; Lu, S.; Wu, Z.; Huang, M.; Wang, X.; Wang, Y.*; Liang, Y.*; Zhu, Y.*; Zheng, Y.; Pan, Y. Nature Communications 2020, 11, 2572.

Computational Design of Enhanced Enantioselectivity in Chiral Phosphoric Acid-Catalyzed Oxidative Desymmetrization of 1,3-Diol Acetals
Meng, S.-S.; Yu, P.; Yu, Y.-Z.; Liang, Y.*; Houk, K. N.*; Zheng, W.-H.* Journal of the American Chemical Society 2020, 142, 8506.

Metal-Free Oxidative B−N Coupling of nido-Carborane with N-Heterocycles
Yang, Z.; Zhao, W.; Liu, W.; Wei, X.; Chen, M.; Zhang, X.; Zhang, X.*; Liang, Y.*; Lu, C.*; Yan, H.* Angewandte Chemie – International Edition 2019, 58, 11886.

Enzyme-Catalysed [6+4] Cycloadditions in the Biosynthesis of Natural Products
Zhang, B.#; Wang, K. B.#; Wang, W.#; Wang, X.#; Liu, F.; Zhu, J.; Shi, J.; Li, L. Y.; Han, H.; Xu, K.; Qiao, H. Y.; Zhang, X.; Jiao, R. H.; Houk, K. N.*; Liang, Y.*; Tan, R. X.*; Ge, H. M.* Nature 2019, 568, 122.

Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters
Zhang, W.#; Zou, Z.#; Wang, Y.; Wang, Y.*; Liang, Y.*; Wu, Z.*; Zheng, Y.; Pan, Y. Angewandte Chemie – International Edition 2019, 58, 624.

Bioorthogonal Cycloadditions: Computational Analysis with the Distortion/Interaction Model and Predictions of Reactivities
Liu, F.; Liang, Y.*; Houk, K. N.* Accounts of Chemical Research 2017, 50, 2297.

Type II Anion Relay Chemistry: Conformational Constraints To Achieve Effective [1,5]-Vinyl Brook Rearrangements
Liu, Q.; Chen, Y.; Zhang, X.; Houk, K. N.; Liang, Y.*; Smith, A. B., III* Journal of the American Chemical Society 2017, 139, 8710.



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