刘颖，女，教授，博士生导师，国家级青年人才计划入选者。国家“优秀青年”基金、江苏省“杰出青年”基金、特聘教授、“双创人才”入选者。2004年从南京大学化学化工学院获得学士学位，2007年从南京大学化学化工学院获得分析化学硕士学位，2012年从美国加州大学河滨分校（University of California Riverside）获得分析化学博士学位。2012-2013年在德国博世集团北美研发中心（Robert Bosch llc Research and Technology Center）任研究员。2013-2015年在加州大学戴维斯分校（University of California Davis）生物医学工程系从事博士后研究工作，并兼任Sersense Inc.生物科技公司项目负责人。2015年7月起任南京大学化学化工学院化学系生命分析化学国家重点实验室教授。

2012-2013年在德国博世集团北美研发中心（Robert Bosch llc Research and Technology Center）任研究员。2013-2015年在加州大学戴维斯分校（University of California Davis）生物医学工程系从事博士后研究工作，并兼任Sersense Inc.生物科技公司项目负责人。2015年7月起任南京大学化学化工学院化学系生命分析化学国家重点实验室教授。

课题组主要研究方向包括：

1）智能响应纳米材料合成与光学性能优化（DNA纳米材料、稀土无机纳米材料等）；

2）生物分析与传感、智能响应的细胞成像与近红外二区活体成像；

3）药物智能递送与疾病/癌症精准诊疗策略开发。

课题组研究目标为：

1）做更“亮”的荧光探针：通过对无机稀土纳米材料的结构设计与表面修饰优化，将其发光强度提高了3个数量级。

2）做更“快”的检测：通过DNA自组装构建局域反应空间增加反应物浓度、提高反应效率，将反应速度由几小时缩短到几分钟。

3）做更“准”的治疗：利用细胞膜表面DNA逻辑运算与近红外光控策略，通过DNA编程对细胞膜进行功能化，实现单细胞行为监测并对细胞功能与生理过程进行监测与调控。

2023

1.Shiyi Bi, Wei Chen, Yanyun Fang, Yingfei Wang, Qing Zhang, Hongqian Guo, Huangxian Ju, Ying Liu* Cancer cell-selective membrane

receptor clustering driven by VEGF secretion for in vivo therapy. J. Am. Chem. Soc. 2023, 145, 5041-5052.

2. Xiaoxian Liu, Yifan Zhu, Caoxin Li, Yanyun Fang, Jinna Chen, Fei Xu, Yanqing Lu, Perry Ping Shum, Ying Liu*, Guanghui Wang* Sing-cell

HER2 quantification via instant signal amplification in microdroplets Anal. Chim. Acta2023, 1251, 340976

2022

1. Yingfei Wang, Wei Chen, Zhong Wang, Yu Zhu, Hongxia Zhao, Kun Wu, Jie Wu, Weihua Zhang, Qing Zhang, Hongqian Guo, Huangxian

Ju, Ying Liu* NIR-II light powered asymmetric hydrogel nanomotors for enhanced immunochemotherapy Angew. Chem. Int. Ed. 2022,

e202212866.

2.Xiaobo Zhang, Weiwei Chen, Xiaoyu Xie, Yue Zhang, Zhicong Chao, Haibo Ma,Ying Liu*,Huangxian Ju* Energy pumping by surface

collectors on upconversion nanoparticles  for extended transfer and efficient self-evaluable photodynamic therapy CCS

Chem.2022,4,1251-1262.

3.Hongxia Zhao, Yuetong Li, Xiaobo Zhang, Kun Wu, Jiahang Lv, Cheng Chen, Huipu Liu, Zhuangzhi Shi, Huangxian Ju, Ying Liu*

Orthogonal excitations of lanthanide nanoparticle up/down conversion emissions via switching NIR lights for in-vivo theranostics

Biomaterials2022, 291, 121873

4.Yanyun Fang, Yawei Yan, Shiyi Bi, Yingfei Wang, Yue Chen, Peipei Xu*, Huangxian Ju, Ying Liu*Screening T-cell activity via a

photodetachable DNA-copolymer nanocage and its therapeutic application Anal. Chem.2022, 94, 13205-13214.

5. Yuchen Zhang, Xing Xing, Hongxia Zhao, Jing Jiang, Ying Liu, Zhenda Lu* Printed hybrid upconversion/perovskite nanoparticle cluster

and its individual photoluminescence imaging Adv. Optical Mater. 2022, 2201841.

6.Jingxing Guo, Ying Liu, Huangxian Ju*, Guangming Lu* From lab to field: surface-enhanced raman scattering based sensing strategies

for on-site analysis. Trends Anal. Chem. 2022, 146,116488.

7. Yuetong Li, Yuxin Xie, Yue Zhang, Hongxia Zhao, Huangxian Ju, Ying Liu* DNA nanomachine activation and Zn²⁺ imaging in living cells

with single NIR irradiation Anal. Chim. Acta2022, 1221, 340149

8.Xinyu Jin, Hongxia Zhao, Zhicong Chao, Xiaofeng Wang, Qing Zhang*, Huangxian Ju, Ying Liu* Self-assembled cupric oxide

nanoclusters for highly efficient chemodynamic therapy Chem. Asian. J. 2022, e202200296

2021

1.Yue Zhang, Weiwei Chen, Yanyun Fang, Xiaobo Zhang, Ying Liu*,Huangxian Ju* Activating a DNA nanomachine via computation

across cancer cell membranes for precise therapy of solid tumors J. Am. Chem. Soc. 2021, 143, 15233-15242.

2.Yuling He, Shuwen Guo, Yue Zhang, Ying Liu*, Huangxian Ju NIR-II reinforced intracellular cyclic reaction to enhance

chemodynamic therapy with abundant H₂O₂ supply Biomaterials 2021, 275, 120962.

3.Yue Zhang, Xiaobo Zhang, Weiwei Zhen, Yuling He, Ying Liu*, Huangxian Ju* Self-assembled micelle responsive to quick NIR light

irradiation for fast drug release and highly efficient cancer therapy J. Control Release 2021, 336, 469-479.

4. Yanyun Fang, Yuetong Li, Yuyi Li, Rong He, Yue Zhang, Xiaobo Zhang, Ying Liu*, Huangxian Ju In situ protease secretion visualization

and metastatic lymph nodes imaging via a cell-membrane anchored upconversion nanoprobe Anal. Chem.2021, 93, 7258-7265.

5. Yuling He, Shuwen Guo, Yue Zhang, Ying Liu*, Huangxian Ju Near-infrared photo-controlled permeability of a biomimetic

 polymersome with sustained drug release and efficient tumor therapy ACS Appl. Mater. Interfaces2021, 13, 14951-14963.

6.Yuling He, Xinyu Jin, Shuwen Guo, Hongxia Zhao,Ying Liu*, Huangxian Ju Conjugated polymer-ferrocence nanoparticle as an NIR-II

light powered nanoamplifier to enhance chemodynamic therapy ACS Appl. Mater. Interfaces2021, 13, 31452-31461.

2020

1.Yue Zhang, Weiwei Chen, Yue Zhang, Xiaobo Zhang, Ying Liu*, Huangxian Ju* Near-infrared photo-switched microRNA amplifier for precise photodynamic therapy of early-stage cancers Angew. Chen. Int. Ed.2020 59, 21454-21459.

2.Yue Zhang, Yue Zhang, Xiaobo Zhang, Yuyi Li, Yuling He, Ying Liu*, Huangxian Ju Photo zipper locked DNA nanomachine with

internal standard for precise miRNA imaging in living cells Chem. Sci. 2020, 11, 6289-6296.

3. Jingxing Guo, Ying Liu, Yuanjiao Yang, Yumei Li, Ruiyong Wang, Huangxian Ju* A filter supported surface-enhanced raman scattering "nose" for point-of-care monitoring of gaseous metabolites of bacteria Anal. Chem. 2020, 92, 5055-5063.

4.Yuyi Li, Xiaobo Zhang, Yue Zhang, Yue Zhang, Yuling He, Ying Liu*, Huangxian Ju Activatable photodynamic therapy with therapeutic

 effect prediction based on a self-correction upconversion nanoprobe. ACS Appl. Mater. Interfaces 2020, 12, 19313-19323.

5.Yingfei Wang, Yuyi Li, Yue Zhang, Kewei Ren, Huangxian Ju, Ying Liu* Express and sensitive detection of multiple miRNAs via DNA

cascade reactors functionalized photonic crystal array. Sci. China Chem.2020, 63, 731-740.

2019

1. Yue Zhang, Yue Zhang, Guobin Song, Yuling He, Xiaobo Zhang, Ying Liu*, Huangxian Ju* A DNA-Azobenzene nanopump fueled by

upconversion luminance for controllable intracellular drug release Angew. Chem. Int. Ed.2019, 58, 18207-18211.

2. Xiaobo Zhang, Weiwei Chen, Xiaoyu Xie, Yuyi Li, Desheng Chen, Zhicong Chao, Chenghui Liu, Haibo Ma, Ying Liu*, Huangxian Ju*

Boosting luminance energy transfer efficiency in upconversion nanoparticles with an energy-concentrating zone Angew. Chem. Int. Ed.

2019, 58, 12117-12122.

3.Yuling He, Shuwen Guo, Lina Wu, Pengwen Chen, Leyong Wang, Ying Liu*, Huangxian Ju* Near-infrared boosted ROS responsive

siRNA delivery and cancer therapy with sequentially peeled upconversion nano-onions Biomaterials2019, 225, 119501

4. Jingxin Guo, Zhihao Zhong, Yumei Li, Ying Liu*, Ruiyong Wang*, Huangxian Ju* “Three-in-One” SERS adhesive tape for rapid sampling, release, and detection of wound infectious pathogens ACS Appl. Mater. Interfaces 2019, 11, 36399-36408.

5.Lina Wu, Yingfei Wang, Rong He, Yue Zhang, Yuling He, Chao Wang, Zhenda Lu, Ying Liu*, Huangxian Ju Fluorescence hydrogel array

based on interfacial cation exchange amplification for highly sensitive microRNA detection Anal. Chim. Acta 2019, 1080, 206-214.

2018

1.Kewei Ren, Yue Zhang, Xiaobo Zhang, Ying Liu*, Min Yang, Huangxian Ju* In situ siRNA assembly in living cells for gene therapy with

microRNA triggered cascade reactions templated by nucleic acids ACS Nano2018, 12, 10797-10806.

2.Kewei Ren, Yifan Xu, Ying Liu*, Min Yang, Huangxian Ju* A responsive “Nano string light” for highly efficient mRNA imaging in living

 cells via accelerated DNA cascade reaction ACS Nano 2018, 12, 263-271.

3. Jingxing Guo, Ying Liu, Yunlong Cheng, Jianqi Li, Huangxian Ju* A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms Chem. Sci. 2018, 9, 5906

4.Yue Zhang, Kewei Ren, Xiaobo Zhang, Zhicong Chao, Yuqin Yang, Deju Ye, Zhihui Dai, Ying Liu*, Huangxian Ju* Photo-tearable tape

close-wrapped upconversion nanocapsules for near-infrared modulated efficient siRNA delivery and therapy Biomaterials 2018, 163,

55.

5.Xiao Meng, Junjie Hu, Zhicong Chao, Ying Liu*, Huangxian Ju, Quan Cheng* Thermoresponsive arrays patterned via photoclick

chemistry: smart MALDI plate for protein digest enrichment, desalting, and direct MS analysis ACS Appl. Mater. Interfaces 2018, 10,

1324-1333.

6.Alexander Lambert, Zhanjun Yang, Wei Cheng, Zhenda Lu, Ying Liu*, Quan Cheng* Ultrasensitive detection of bacterial protein

toxins on patterned microarray via surface plasmon resonance imaging with signal amplification by conjugate nanoparticle clusters

ACS Sens. 2018, 3, 1639-1646.

7.Jingjing Zhu, Xiao Meng, Chi Zhang, Jie Bian, Zhenda Lu, Ying Liu*, Weihua Zhang* Tailoring a nanostructured plasmonic absorber

for high efficiency surface-assisted laser desorption/ionization Phys. Chem. Chem. Phys. 2018, 20, 3424.

Before 2017:

1.  Ying Liu, Huangxian Ju* Luminescence spectroscopy of semiconductors Anal. Bioanal. Chem. 2017, 6, 1473.

2.Ying Liu, Ali Rahimian, Sergiy Krylyuk, Tam Vu, Bruno Crulhas, Gulnaz Stybayeva, Meruyert Imanbekova, Dong-Sik Shin, Albert

Davydov, Alexander Revzin* Nanowire aptasensors for electrochemical detection of cell-secreted cytokines ACS Sens. 2017, 2, 1644.

3. Bruno P. Crulhas, Dustin Hadley, Ying Liu, Dong-Sik Shin, Gulnaz Stybayeva, Meruyert Imanbekova, Ashley E. Hill, Valber Pedrosa,

Alexander Revzin* An electrochemical aptasensor for detection of bovine interferon gamma Anal. Methods, 2017, 9, 4527.

4. Kewei Ren,  Ying Liu, Jie Wu, Yue Zhang, Jing Zhu, Min Yang, Huangxian Ju* A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery Nat. Commun. 2016, 7, 13580.

5. Ying Liu, Ying Liu, Zimple Matharu, Ali Rahimian, Alexander Revzin* Detecting multiple cell-secreted cytokines from the same

aptamer functionalized electrode Biosens. Bioelectron. 2015, 64, 43.

6. Qing Zhou, Kyungjin Son, Ying Liu, Alexander Revzin* Biosensors for cell analysis Annu. Rev. Biomed. Eng. 2015, 17, 165.

7. Yandong Gao, Qing Zhou, Zimple Matharu, Ying Liu, Timothy Kwa, Alexander Revzin* A mathematical method for extracting cell

secretion rate from affinity biosensors continuously monitoring cell activity Biomicrofluidics2014, 8, 021501.

8. Timothy Kwa, Qing Zhou, Yandong Gao, Ali Rahimian, Lydia Kwon, Ying Liu, Alexander Revzin* Reconfigurable microfluidics with

integrated aptasensors for monitoring intercellular communication Lab on a Chip 2014, 14, 1695.

9.  Ying Liu, Michael C. Young, Orly Moshe, Quan Cheng*, Richard J Hooley* A membrane-bound synthetic receptor that promotes

growth of a polymeric coating at the bilayer-water interface Angew. Chem. Int. Ed. 2012, 51, 7748.

10. Chuanbo Gao, Zhenda Lu, Ying Liu, Qiao Zhang, Miaofang Chi, Quan Cheng, Yadong Yin* Highly stable silver nanoplates for surface

plasmon resonance biosensing Angew. Chem. Int. Ed.2012, 51, 5629.

11. Ying Liu, Quan Cheng* Detection of membrane binding proteins by surface plasmon resonance with an all-aqueous amplification

scheme Anal. Chem. 2012, 84, 3179.

12. Ying Liu, Toshiaki Taira, Michael C Young, Dariush Ajami, Juluis Rebek Jr.* Quan Cheng* Richard J Hooley* Protein recognition by a

self-assembled deep cavitand monolayer on a gold substrate Langmuir 2012, 28, 1391.

13.   Ying Liu, Puhong Liao, Quan Cheng* Richard J Hooley* Protein and small molecule recognition properties of deep cavitands in a

supported lipid membrane determined by calcination-enhanced SPR spectroscopy J. Am. Chem. Soc. 2010, 132, 10383.

14. Ying Liu, Yi Dong, Jessica Jauw, Matthew J Linman, Quan Cheng* Highly sensitive detection of protein toxins by surface plasmon

resonance with biotinylation based inline atom transfer radical polymerization amplification Anal. Chem. 2010, 82, 3679.

15. Ying Liu, Jianping Lei, Huangxian Ju* Amperometric sensor for hydrogen peroxide based on electric wire composed of horseradish

peroxidase and toluidine blue-multiwalled carbon nanotubes nanocomposite Talanta 2008, 74, 965

16. Ying Liu, Shuo Wu, Huangxian Ju*, Li Xu Amperometric glucose biosensing of gold nanoparticles and carbon nanotube multilayer

membranes Electroanalysis 2007, 19, 986.

17. Shuo Wu, Huangxian Ju*, Ying Liu Conductive mesocellular silica-carbon nanocomposite foams for immobilization, direct

electrochemistry, and biosensing of proteins Adv. Funct. Mater.2007, 17, 585

18. Ying Liu, Yilong Yan, Jianping Lei*, Fan Wu, Huangxian Ju* Functional multiwalled carbon nanotube nanocomposite with iron

picket-fence porphyrin and its electrocatalytic behavior Electrochem. Commun. 2007, 9, 2564.

表面材料分析，研究生专业必修课

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