陈子轩，男，1987年生，南京大学化学化工学院副教授，博士生导师，基金委优秀青年科学基金获得者。

2015年博士毕业于南京大学化学化工学院，2016年起在南京大学工作，任副研究员，2021年起任副教授。主要研究方向为：1）光学显微仪器的研制；2）单细胞、单分子、单颗粒传感；3）纳米电分析化学。在Nat. Commun.、Sci. Adv.、J. Am. Chem. Soc.、Angew. Chem.等期刊上发表SCI论文40余篇，主持了国家优秀青年基金、面上项目等科研项目。

2021-至今，南京大学化学化工学院，副教授

2016-2020年，南京大学化学化工学院，副研究员

1）单分子、单细胞、单颗粒

2）拉曼显微成像

3）电化学发光成像

代表论文：

(1) Tang, W.; Tang, Z.; Li, J.; Yang, R.; Jiang, L.-P.; Zhu, W.; Zhu, J.-J.; Chen, Z. Digital Decoding of Multicomponent Protein Systems via Nanocavity-Confined Single-Molecule Raman Fingerprinting. Angew. Chem. Int. Ed. 2025, n/a, e22371.

(2) Zhou, K.; Tang, Z.; Liu, Y.; Xing, Z.; Zhu, J.-J.; Chen, Z. Ultrabright Gold Nanoclusters with Intra-Cluster Hydrogen Bonding Enable Near-Zero-Thickness Electrochemiluminescence Imaging of Subcellular Structures. Angew. Chem. Int. Ed. 2025, n/a, e10193.

(3) Liu, R.; Tang, Z.; Xia, Q.; Chen, Z.; Zhu, J.-J. Spinning Top-like Nanoprobes for Direct Visualization of Cooperative Ca2+-Binding-Induced Conformational Switching in Single Calmodulin Molecules. J. Am. Chem. Soc. 2025, 147, 28251-28258.

(4) Tu, K.; Xu, X.; Li, J.; Zhu, W.; Chen, Z. Thin-Layer Covalent Organic Framework-Coated Gold Superstructures for Label-Free Raman Spectroscopic Monitoring of Multiple Volatile Organic Compounds. Anal. Chem. 2025, 97, 15173-15180.

(5) Tang, Z.; Wu, J.; Wu, S.; Tang, W.; Zhang, J.-R.; Zhu, W.; Zhu, J.-J.; Chen, Z. Single molecule–driven nanomotors reveal the dynamic-disordered chemomechanical transduction of active enzymes. Sci. Adv. 2025, 11, eads0446.

(6) Chen, X.; Gao, Y.; Qi, Y.; Li, J.; Hu, T. Y.; Chen, Z.; Zhu, J.-J. Label-Free Raman Probing of the Intrinsic Electric Field for High-Efficiency Screening of Electricity-Producing Bacteria at the Single-Cell Level. Angew. Chem. Int. Ed. 2025, 64, e202416011.

(7) Yang, R.; Cai, Y.; Qi, Y.; Tang, Z.; Zhu, J.-J.; Li, J.; Zhu, W.; Chen, Z. How local electric field regulates C–C coupling at a single nanocavity in electrocatalytic CO2 reduction. Nat. Commun. 2024, 15, 7140.

(8) Wu, S.; Tang, W.; Wang, Z.; Tang, Z.; Zheng, P.; Chen, Z.; Zhu, J.-J. High Dynamic Range Probing of Single-Molecule Mechanical Force Transitions at Cell–Matrix Adhesion Bonds by a Plasmonic Tension Nanosensor. JACS Au. 2024, 4, 1155-1165.

(9) Wu, R.; Cao, Y.; Liu, Y.; Zhou, Y.; Chen, Z.; Zhu, J.-J. Alkynyl Ligands Templated Assemblies of Silver Nanoclusters with Exceptional Electrochemiluminescence Activity for Pancreatic Cancer Specific tsRNAs Measurement. Anal. Chem. 2024, 96, 19396-19403.

(10) Gao, Y.; Wu, J.; Xia, Q.; Liu, J.; Zhu, J.-J.; Zhang, J.-R.; Chen, X.; Zhu, W.; Chen, Z. Operando Spectroscopic Elucidation of the Bubble Sunshade Effect in Inorganic–Biological Hybrids for Photosynthetic Hydrogen Production. ACS Nano. 2024, 18, 14546-14557.

(11) Li, J.; Qi, Y.; Yang, R.; Chen, X.; Chen, Z.; Zhu, J.-J. Intellectualized Visualization of Single-Particle Raman Spectra for Sensitive Detection and Simultaneous Multianalysis of Heavy Metal Ions. Anal. Chem. 2023, 95, 14736-14745.

(12) Gao, D.; Tang, Z.; Chen, X.; Wu, R.; Tian, Y.; Min, Q.; Zhang, J.-R.; Chen, Z.; Zhu, J.-J. Reversible Regulation of Long-Distance Charge Transport in DNA Nanowires by Dynamically Controlling Steric Conformation. Nano Lett. 2023, 23, 4201-4208.

(13) Tang, Z.; Liu, R.; Chen, X.; Gao, D.; Zhang, J.-R.; Zhu, J.-J.; Chen, Z. Plasmonic Probing Single-Cell Bio-Current Waves with a Shrinking Magnetite Nanoprobe. ACS Nano. 2022, 16, 20842-20850.

(14) Chen, X.; Gao, Y.; Zhan, J.; Xia, Q.; Chen, Z.; Zhu, J.-J. Spatiotemporal-Resolved Hyperspectral Raman Imaging of Plasmon-Assisted Reactions at Single Hotspots. Anal. Chem. 2022, 94, 8174-8180.

《仪器分析化学》

《仪器分析实验》

《化学与材料》