陈子轩，男，1987年生，南京大学化学学院副教授，博士生导师，国家优秀青年科学基金获得者。

2015年博士毕业于南京大学化学化工学院，2016年起在南京大学工作，任副研究员，2021年起任副教授。主要研究方向为：1）光学显微仪器的研制；2）单细胞、单分子、单颗粒传感；3）纳米限域拉曼光谱研究。在Nat. Commun.、Sci. Adv.、J. Am. Chem. Soc.、Angew. Chem.等期刊上发表SCI论文40余篇，主持了国家优秀青年基金、面上项目等科研项目。欢迎本科生、直博生、推免生联系进组。

2021-至今，南京大学化学化工学院，副教授

2016-2020年，南京大学化学化工学院，副研究员

1）单分子、单细胞、单颗粒

2）拉曼显微成像

3）电化学发光成像

代表论文：

1. Xing, Z.; Zhang, Z.; Liu, R.; Zhuang, J.; Gou, X.; Jiang, L.-P.; Ma, C.; Zhu, J.-J.; Chen, Z., Electrochemiluminescence microscopy for real-time, single-cell imaging of surface charge in electroactive bacteria. Nature Communications 2026, 10.1038/s41467-026-75226-y.

2. Li, J.; Wu, R.; Yang, R.; Tang, W.; Liu, Y.; Zhu, J.-J.; Zhu, W.; Chen, Z., Operando Nanocavity-Confined Raman Spectroscopy Uncovers a Drilling-Shearing Mechanism in Nanoplastic Photodegradation. Journal of the American Chemical Society 2026,148 (25), 26661-26671.

3. Tang, W.; Tang, Z.; Li, J.; Yang, R.; Jiang, L.-P.; Zhu, W.; Zhu, J.-J.; Chen, Z., Digital Decoding of Multicomponent Protein Systems via Nanocavity-Confined Single-Molecule Raman Fingerprinting. Angewandte Chemie International Edition 2026,65 (6), e22371.

4. Zhou, K.; Tang, Z.; Liu, Y.; Xing, Z.; Zhu, J.-J.; Chen, Z., Ultrabright Gold Nanoclusters with Intra-Cluster Hydrogen Bonding Enable Near-Zero-Thickness Electrochemiluminescence Imaging of Subcellular Structures. Angewandte Chemie 2025,137 (52), e10193.

5. Liu, R.; Tang, Z.; Xia, Q.; Chen, Z.; Zhu, J.-J., Spinning Top-like Nanoprobes for Direct Visualization of Cooperative Ca2+-Binding-Induced Conformational Switching in Single Calmodulin Molecules. Journal of the American Chemical Society 2025,147 (31), 28251-28258.

6. Tang, Z.; Wu, J.; Wu, S.; Tang, W.; Zhang, J.-R.; Zhu, W.; Zhu, J.-J.; Chen, Z., Single molecule–driven nanomotors reveal the dynamic-disordered chemomechanical transduction of active enzymes. Science Advances 11 (5), eads0446.

7. Chen, X.; Gao, Y.; Qi, Y.; Li, J.; Hu, T. Y.; Chen, Z.; Zhu, J.-J., Label-Free Raman Probing of the Intrinsic Electric Field for High-Efficiency Screening of Electricity-Producing Bacteria at the Single-Cell Level. Angewandte Chemie International Edition 2025,64 (4), e202416011.

8. Yang, R.; Cai, Y.; Qi, Y.; Tang, Z.; Zhu, J.-J.; Li, J.; Zhu, W.; Chen, Z., How local electric field regulates C–C coupling at a single nanocavity in electrocatalytic CO2 reduction. Nature Communications 2024,15 (1), 7140.

9. Gao, Y.; Wu, J.; Xia, Q.; Liu, J.; Zhu, J.-J.; Zhang, J.-R.; Chen, X.; Zhu, W.; Chen, Z., Operando Spectroscopic Elucidation of the Bubble Sunshade Effect in Inorganic–Biological Hybrids for Photosynthetic Hydrogen Production. ACS Nano 2024,18 (22), 14546-14557.

10. Li, J.; Qi, Y.; Yang, R.; Chen, X.; Chen, Z.; Zhu, J.-J., Intellectualized Visualization of Single-Particle Raman Spectra for Sensitive Detection and Simultaneous Multianalysis of Heavy Metal Ions. Analytical Chemistry 2023,95 (39), 14736-14745.

11. Gao, D.; Tang, Z.; Chen, X.; Wu, R.; Tian, Y.; Min, Q.; Zhang, J.-R.; Chen, Z.; Zhu, J.-J., Reversible Regulation of Long-Distance Charge Transport in DNA Nanowires by Dynamically Controlling Steric Conformation. Nano Letters 2023,23 (10), 4201-4208.

12. Tang, Z.; Liu, R.; Chen, X.; Gao, D.; Zhang, J.-R.; Zhu, J.-J.; Chen, Z., Plasmonic Probing Single-Cell Bio-Current Waves with a Shrinking Magnetite Nanoprobe. ACS Nano 2022,16 (12), 20842-20850.

13. Chen, X.; Gao, Y.; Zhan, J.; Xia, Q.; Chen, Z.; Zhu, J.-J., Spatiotemporal-Resolved Hyperspectral Raman Imaging of Plasmon-Assisted Reactions at Single Hotspots. Analytical Chemistry 2022,94 (23), 8174-8180.

14. Ma, C.; Wu, S.; Zhou, Y.; Wei, H.-F.; Zhang, J.; Chen, Z.; Zhu, J.-J.; Lin, Y.; Zhu, W., Bio-Coreactant-Enhanced Electrochemiluminescence Microscopy of Intracellular Structure and Transport. Angewandte Chemie International Edition 2021,60 (9), 4907-4914.

《仪器分析化学》

《仪器分析实验》

《化学与材料》