Prof. Wei Wu received his Ph.D. degree from the Institute of Chemistry, Chinese Academy of Sciences in 2004. Thereafter, he became a postdoctoral research associate in the CNRS in Strasbourg (France) in 2005-2006 and in the Department Chemistry of Hong Kong University of Science and Technology in 2006-2007 successively. Since September 2007, he joined the College of Chemistry and Chemical Engineering in Nanjing University and started his own independent academic career. He was supported by the National Natural Science Funds for Excellent Young Scholar in 2014 and was supported by the “DengFeng Talent Supporting Program (Level B)” in 2015.

2015/01 – now，College of Chemistry & Chemical Engineering, Nanjing University, professor

2010/01 – 2015/01，College of Chemistry & Chemical Engineering, Nanjing University, associate professor

2007/9 - 2010/01，College of Chemistry & Chemical Engineering, Nanjing University, lecturer

2006/2 - 2007/9，Department Chemistry, Hong Kong University of Science and Technology，postdoc

2004/11 –2005/12，CNRS in France，postdoc

1.Synthesis and biological applications of unimolecular polymer nanomaterials.

2.Synthesis and biological applications of optical probes.

Representative work

Representative papers:

1.        Ying Sun, Yongmin Zhang, Mengke Liang, Jia Li, Xiqun Jiang,* Wei Wu*.Cyclodextrin-Catalyzed Diels-Alder Reaction for the Syntheses of Cyclodextrin Polyrotaxanes, Molecular Tubes, and Molecular Shuttles, Macromolecules 2024, 10.1021/acs.macromol.4c00892.

2.        Bo Yu, Weijie Wang, Yongmin Zhang, Ying Sun, Cheng Li, Xu Zhen,* Xiqun Jiang,* Wei Wu*.Enhancing the tumor penetration of multiarm polymers by collagenase modification, Biomater. Sci. 2024, 12, 2302-2311.

3.        Chongzhi Wang, Yikai Tang, Yang Yuan, Cheng Li, Wei Wu*, Xiqun Jiang*. ‘Phenylboronic acid-modified nanoscale multi-arm polymers for tumor-targeted therapy’, Biomater. Sci. 2023, 11, 4281-4288.

4.        Mengke Liang, Luyu Liu, Ying Sun, Jia Li, Ling’e Zhang*, Xiqun Jiang*, Wei Wu*. ‘Furan-modified thiadiazolo quinoxaline as an electron acceptor for constructing second near-infrared aggregation-induced emission fluorophores for beyond 1300 nm fluorescence/photoacoustic imaging and photothermal therapy’, Aggregate2023, e458.

5.        Panpan Xiao, Ying Sun,Mengke Liang, Shuo Yang, Jia Li, Ling’e Zhang*, Xiqun Jiang*, Wei Wu*.‘A fluorophore with dithienopyrrole donor for beyond 1300 nm NIR-II fluorescence/photoacoustic dual-model imaging and photothermal therapy’,Mater. Today Nano. 2023, 24, 100404.

6.        Bo Yu,Ying Sun, Panpan Xiao, Cheng Li, KangJun Yuan, Ling’e Zhang*, Xiqun Jiang*, Wei Wu*.‘Size Control and Biological Properties of PAMAM-Cored Multiarm Block Copolymers’, ACS Appl. Bio Mater.2023, 6, 2426−2434.

7.        Panpan Xiao, Mengke Liang, Shuo Yang, Ying Sun, Jia Li,Zhewei Gu, Ling’e Zhang*,Quli Fan,Xiqun Jiang*, Wei Wu*. ‘A ratiometric near-infrared fluorescence/photoacoustic dual-modal probe with strong donor dithienopyrrole for in vivo nitric oxide detection’, Biomaterials2023, 294, 121993.

8.        Ruonan Wang, Panpan Xiao, Bo Yu, Ying Sun, Jia Li, Ling’e Zhang*, Xiqun Jiang*, Wei Wu*. ‘Fluorination Effects on the Drug Delivery Property of Cylindrical Polymer Brushes’, ACS Appl. Bio Mater.2022, 5, 5924−5932.

9.        Jia Li, Shun Li, Shuo Yang, Mengke Liang, Xiqun Jiang, Wei Wu*. ‘A Semiconductor Polymer with Strong NIR-II Absorption for Photoacoustic Imaging and Photothermal Therapy’, ACS Appl. Bio Mater.2022, 5, 2224−2231.

10.    Changfeng Yin, Panpan Xiao, Mengke Liang, Jia Li, Ying Sun, Xiqun Jiang, Wei Wu*. ‘Effects of iRGD conjugation density on the in vitro and in vivo properties of cylindrical polymer brushes’, Biomater. Sci.2022, 10, 3236–3244.

11.    Ruonan Wang, Shuo Yang, Panpan Xiao, Ying Sun, Jia Li, Xiqun Jiang, Wei Wu*. ‘Fluorination and Betaine Modification Augment the Blood-Brain Barrier-Crossing Ability of Cylindrical Polymer Brushes’, Angew. Chem. Int. Ed. 2022,e202201390.

12.    Changren Liu, Ruonan Wang, Ying Sun, Changfeng Yin, Zhewei Gu, Wei Wu*, Xiqun Jiang. ‘An Orthogonal Protection Strategy for Synthesizing Scaffold-Modifiable Dendrons and Their Application in Drug Delivery’, ACS Central Sci. 2022, 8, 258-267.

13.    Ruonan Wang, Changfeng Yin, Changren Liu, Ying Sun, Panpan Xiao, Jia Li, Shuo Yang, Wei Wu*, Xiqun Jiang. ‘Phenylboronic Acid Modification Augments the Lysosome Escape and Antitumor Efficacy of a Cylindrical Polymer Brush-Based Prodrug’, J. Am. Chem. Soc. 2021,143, 20927−20938.

14.    Jia Li, Ruonan Wang, Ying Sun, Panpan Xiao, Shuo Yang, Xin Wang, Quli Fan, Wei Wu*, Xiqun Jiang. ‘A NIR-II Fluorophore with Dithienylethene as the Electron Donor for Fluorescence/Photoacoustic Dual-Model Imaging and Photothermal Therapy’, ACS Appl. Mater. Interfaces 2021, 13, 54830−54839.

15.    Changfeng Yin, Ruonan Wang, Ying Sun, Shun Li, Xiaoke Zhang, Jie Gu, Wei Wu*, Xiqun Jiang*. ‘The in vitro and in vivo properties of ringlike polymer brushes’, Nano Today 2021, 41, 101293.

16.    Changren Liu, Ling’e Zhang, Sensen Zhou, Xiaoke Zhang, Wei Wu*, Xiqun Jiang. ‘A Dendron-Based Fluorescence Turn-On Probe for Tumor Detection’, Chem. Eur. J. 2020, 26, 13022.

17.    Shun Li, Tianyuan Cheng, Changfeng Yin, Sensen Zhou, Quli Fan,Wei Wu*, Xiqun Jiang. ‘Phenothiazine versus Phenoxazine: Structural Effects on the Photophysical Properties of NIR-II AIE Fluorophores’, ACS Appl. Mater. Interfaces 2020, 12, 43466.

18.    Shun Li, Changfeng Yin, Ruonan Wang, Quli Fan,Wei Wu*, Xiqun Jiang. ‘Second Near-Infrared Aggregation-Induced Emission Fluorophores with Phenothiazine Derivatives as the Donor and 6,7-Diphenyl-[1,2,5]Thiadiazolo[3,4-g]Quinoxaline as the Acceptor for in Vivo Imaging’, ACS Appl. Mater. Interfaces 2020, 12, 20281.

19.    Ling’e Zhang, Changren Liu, Sensen Zhou, Ruonan Wang, Quli Fan, Dongfang Liu, Wei Wu*, Xiqun Jiang. ‘Improving Quantum Yield of a NIR-II Dye by Phenylazo Group’, Adv. Healthcare Mater.2020, 9, 1901470.

20.    Ling’e Zhang, Zhengkui Zhang, Changren Liu, Xiaoke Zhang, Quli Fan, Wei Wu*, Xiqun Jiang. ‘NIR-II Dye-Labeled Cylindrical Polymer Brushes for in Vivo Imaging’,ACS Macro Lett. 2019, 8, 1623-1628.

21.    Zhengkui Zhang, Ling'e Zhang, Jiaojiao Zhao, Cheng Li, Wei Wu*, Xiqun Jiang. ‘Length Effects of Cylindrical Polymer Brushes on their in Vitro and in Vivo Properties’, Biomater. Sci. 2019,7, 5124-5131.

22.    Zhengkui Zhang, Changren Liu, Cheng Li, Wei Wu*, Xiqun Jiang*. ‘Shape Effects of Cylindrical versus Spherical Unimolecular Polymer Nanomaterials on in Vitro and in Vivo Behaviors’, Research 2019,Article ID 2391486.

23.    张丹，武伟*，蒋锡群. ‘单分子聚合物纳米材料的可控合成及生物应用’，高分子学报 2019，(3): 199-208.

24.    Jialiang Zhang, Ling’e Zhang, Shun Li, Changfeng Yin, Cheng Li, Wei Wu*, Xiqun Jiang*. ‘Modification of α-Cyclodextrin Polyrotaxanes by ATRP for Conjugating Drug and Prolonging Blood Circulation’, ACS Biomater. Sci. Eng. 2018, 4(6), 1963–1968.

25.    Yajun zhang, Zhengkui Zhang, Changren Liu, Weizhi Chen, Cheng Li, Wei Wu*, Xiqun Jiang*. ‘Synthesis and Biological Properties of Water-Soluble Polyphenylthiophene Brushes with Poly(Ethylene Glycol)/Polyzwitterion Side Chains’, Polym. Chem. 2017, 8, 1672–1679.

26.    Yajun zhang, Zhengkui Zhang, Weizhi Chen, Cheng Li, Wei Wu*, Xiqun Jiang. ‘Synthesis and Cellular Uptake Behaviour of beta-Cyclodextrin Polyrotaxane’，Acta Polym. Sinica 2017, (2): 306-314.

27.    Yajun zhang, Weizhi Chen, Chenchen Yang, Quli Fan, Wei Wu*, Xiqun Jiang*. ‘Enhancing Tumor Penetration and Targeting Using Size-Minimized and Zwitterionic Nanomedicines’, J. Controlled Release 2016, 237(1): 115-124.

28.    Wei Wu*, Wouter Drissen, Xiqun Jiang*. ‘Oligo(ethylene glycol)-Based Thermosensitive Dendrimers and Their Tumor Accumulation and Penetration’, J. Am. Chem. Soc. 2014, 136(8): 3145-3155.

29.    Shuling Yu, Yajun Zhang, Xin Wang, Xu Zhen, Zhaoheng Zhang, Wei Wu*, Xiqun Jiang*. ‘Synthesis of Paclitaxel-Conjugated β-Cyclodextrin Polyrotaxane and Its Antitumor Activity’, Angew. Chem. Int. Ed. 2013, 52(28): 7272-7277.

30.    Jing Wang, Zhaoheng Zhang, Xin Wang, Wei Wu*, Xiqun Jiang*. ‘Size- and Pathotropism-Driven Targeting and Washout-Resistant Effects of Boronic Acid-Rich Protein Nanoparticles for Liver Cancer Regression’, J. Controlled Release 2013, 168(1): 1-9.

31.    Luzhong Zhang, Ying Lin, Jingjing Wang, Wei Yao, Wei Wu*, Xiqun Jiang*. ‘A Facile Strategy for Constructing Boron-Rich Polymer Nanoparticles via Boronic Acid-Related Reaction’, Macromol. Rapid Commun. 2011, 32(6): 534-539.

32.    Wei Wu, Rutian Li, Xiaochen Bian, Zhenshu Zhu, Dan Ding, Xiaolin Li, Zhijun Jia, Xiqun Jiang*, Yiqiao Hu. ‘Covalently Combining Carbon Nanotubes with Anticancer Agent: Preparation and Antitumor Activity’, ACS Nano 2009, 3(9): 2740-2750.