近期代表性成果

12.Shanqing Huang,^†1 Ying Wang,^†1 Chuangxu Cai,¹ Xiuyun Xiao,¹ Shulei Liu,² Yeying Ma,¹ Xiangqian Xie,¹ Yong Liang,¹ Hao Chen,¹ Jiapeng Zhu,⁴ Julian D. Hegemann,^*3 Hongwei Yao,^*2 Wanqing Wei^*5 and Huan Wang^*1, Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions, Angew. Chem. Int. Ed. 2022, 61, e202211382.

11. Lei Liu, Xinlong Fan, Boning Wang, Hong Deng,Tianhang Wang,Jie Zheng, Jun Chen, Zhuangzhi Shi^* and Huan Wang*, P(III)-Directed Late-Stage Ligation and Macrocyclization of Peptides with Olefins by Rhodium Catalysis Angew. Chem. Int. Ed. 2022,61, e202206177.

10. Chang Zhao,^1,3 Wangjian Sheng,^2,3 Ying Wang,² Jie Zheng,² Xiangqian Xie,² Yong Liang,²  Wanqing Wei,^2* Rui Bao^1* and Huan Wang^2*, Conformational Remodeling Enhances Activity of Lanthipeptide Zinc-metallopeptidases, Nat. Chem. Biol. 2022, 18, 724-732 (³Equal contribution)

9. Yingying Zhang,^† Zhilai Hong,^†  Liang Zhou,^†  Zhenkun Zhang, Ting Tang, Erpeng Guo, Jie Zheng, Ciji Wang, Lei Dai, Tong Si* and Huan Wang*, Biosynthesis of Gut-Microbiota-Derived Lantibiotics Reveals a Subgroup of S8 Family Proteases for Class III Leader Removal, Angew. Chem. Int. Ed. 2022, 61, e202114414. (^†Equal contribution)

8. Tengfang Long,^† Lei Liu,^† Youqi Tao, Wanli Zhang, Jiale Quan, Jie Zheng, Julian D. Hegemann, Motonari Uesugi, Wenbing Yao, Hong Tian* and Huan Wang*, Light-controlled Tyrosine Nitration of Proteins, Angew. Chem. Int. Ed. 2021, 60, 13414-13422. (^†Equal contribution)

7. Jingxia Lu, Yuan Wu, Yuqing Li and Huan Wang*,  Utilization of Lanthipeptide Synthetases is a General Strategy for the  Biosynthesis of 2-Aminovinyl-Cysteine Motifs in Thioamitides, Angew. Chem. Int. Ed. 2021, 60, 1951-1958.

6. Zengbing Bai, Chuangxu Cai, Wangjian Sheng, Yuxiang Ren and Huan Wang*, Late-Stage Peptide Macrocyclization via Palladium-Catalyzed Site-selective C-H Olefination of Tryptophan, Angew. Chem. Int. Ed. 2020, 59, 14686-14692.

5. Jiantao Tan, Jie Wu, Shu Liu, Hequan Yao and Huan Wang*, Macrocyclization of Peptidoarylacetamides with Self-assembly Properties through Late-stage Palladium-catalyzed C(sp²)-H Olefination, Sci. Adv. 2019, 5, eaaw0323.

4. Shaoming Chen, Bing Xu, Erquan Chen, Jiaqi Wang, Jingxia Lu, Huiming Ge and Huan Wang*, Zn-dependent Bifunctional Proteases are Responsible for Leader Peptide Processing of Class III Lanthipeptides, Proc. Natl. Acad. Sci. U S A. 2019, 116, 2533-2538.

3. Qunfeng Luo, Youqi Tao, Wangjian Sheng, Jingxia Lu and Huan Wang*, Dinitroimidazoles as Bifunctional Bioconjugation Reagents for Protein Functionalization and Peptide Macrocyclization, Nat. Commun. 2019, 10, 142.

2. Jian Tang, Hongfei Chen, Yadong He, Wangjian Sheng, Qingqing Bai and Huan Wang*,  Peptide-guided functionalization and macrocyclization of bioactive  peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation, Nat. Commun. 2018, 9, 3383

1. Zengbing Bai, Chuangxu Cai, Zonglun Yu and Huan Wang*, Backbone-Enabled Directional Peptide Macrocyclization through Late-Stage Palladium-Catalyzed δ-C(sp2)-H Olefination, Angew. Chem. Int. Ed. 2018, 57, 13912-13916.