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    发布时间:2018-10-08 14:33:58    点击:560

生命分析化学学术报告


报告题目: Development of second generation of molecular imaging probes for Amyloid beta
报 告 人: Prof. Chongzhao Ran
          Martinos Center for Biomedical Imaging
          Massachusetts General Hospital, Harvard Medical School
Email: cran@nmr.mgh.harvard.edu
时  间:2018年10月11号(周四)下午2 : 30
地  点:仙林校区化学楼G-211
邀请人:叶德举
 
Abstract: Amyloid beta (A) deposits and Tau tangles are the two characteristic biomarkers for Alzheimer’s disease (AD). In the progression of AD, various A subtypes, including soluble and insoluble As, co-exist, but soluble As are the dominant species at the pre-symptomatic stage. Studies show that soluble Aβs such as oligomers are more neurotoxic than insoluble deposits (fibrils and plaques) and can serve as biomarkers for the pre-symptomatic stages of AD. However, the current probes (the first generation (1stG)) can only detect the abnormal A deposits around 5 years before the clinical syndrome, leaving a 25-year gap between the early pathogenesis and the imaging detection. To overcome the intrinsic limitation of the 1st G probe, we have systematically investigated near infrared fluorescent (NIRF) curcuminoids as the new scaffold for detecting As. In this presentation, I will also discuss our tracer design half-curcuminoids as the novel second generation of PET tracers for As. With the optimized PET tracers, we will discuss results from preclinical PET imaging with mice. For a long term, we will advance the probes for future translational studies.
 
Biography: Chongzhao Ran, Ph.D., is an Assistant Professor in Radiology, Massachusetts General Hospital and Harvard Medical School. He received Master Degree in Medicinal Chemistry from China Pharmaceutical University, and Ph.D. in Medicinal Chemistry from Shanghai Institute of Pharmaceutical Industry, China. He did his postdoctoral training at University of Chicago and Harvard Medical School. Dr. Ran’s research focuses on the development of molecular imaging probe and imaging technologies. Dr. Ran has published nearly 60 papers in the fields of chemistry and molecular imaging, some in high-ranking journals such as PNAS and J. Amer. Chem. Soc.. In the past years, his research group has successfully developed numerous near-infrared fluorescence (NIRF) imaging probes, which revolve around their own brand CRANAD-X, for in vivo detection of amyloid beta in mouse models of Alzheimer’s disease (AD). Particularly, Dr. Ran’s research has been focusing on seeking “smart” NIR probes for soluble amyloid beta species, which are widely believed to be the most neurotoxic species at the early stage of AD. Recently, his research group has been successfully designed and synthesized 2nd generation PET tracers for amyloid beta species.
Website: https://scholar.harvard.edu/ranlab
 
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