题 目：Metaproteomics for the study of the human microbiome
报告人：Daniel Figeys 教授
单 位：Faculty of Medicine, University of Ottawa, Canada
My laboratory is interested to study the human-microbiome interactions using omics approaches. To date, the majority of host-microbiome interactions have been studied by genomics. Instead, we focus on multiomic approaches to get a more complete view of the biomolecular changes in the host and microbiome. I will first briefly present an application of metaproteomics and metagenomics to better understand the human-microbiome interaction and to identify key bacteria in Inflammatory Bowel Disease (IBD) in children. A second challenge in host-microbiome interaction is the lack of assays to rapidly assess microbiome treatments. I will present a new ex vivo assay for microbiome that can be used to assess the effects of different compounds on individual microbiome. Finally, I will present a new bioinformatics approach for the identification of proteins from microbiome.
Daniel Figeys is the Chair and professor in the Department of Biochemistry, Microbiology and Immunology, at the University of Ottawa, and a Tier-I Canada Research Chair in Proteomics and Systems Biology. He was the inaugural Director of the Ottawa Institute of Systems Biology from 2004-2013. He is also a Visiting Professor for Senior International Scientists, Chinese Academy of Sciences. Daniel obtained a B.Sc. and a M.Sc. in chemistry from the Université de Montréal. He obtained a Ph.D. in chemistry from the University of Alberta with Dr. Norm Dovichi and did his postdoctoral studies with Dr. Ruedi Aebersold at the University of Washington. He has published over 160 articles (with many published in leading scientific journals such as Nature, Cell and PNAS), cited over 12,000 times, and has an H-index of 48.