题 目：Functional Proteomics for Precision Cancer Medicine
报告人：Shawn Li (李顺成) 教授
Canada Research Chair in Functional Genomics and Proteomics
单 位：Department of Biochemistry, Western University, Canada
Proteins in the cell are subjected to numerous post-translational modifications (PTM). PTMs not only greatly increase the size of the proteome, they also enrich protein function and enable dynamic control of essential cellular processes such as proliferation, differentiation, and apoptosis. We are interested in understanding the mechanism of signal transduction mediated by protein phosphorylation and methylation in cells under normal or pathological conditions. A major focus of my lab is to identify novel tyrosine phosphorylation and lysine methylation sites and to characterize their functions in tumorigenesis and drug resistance. By combining proteomic techniques such as mass spectrometry and peptide/protein microarrays with conventional biochemical, molecular, and cellular approaches, we hope to uncover novel PTM events in an effective and systematic manner, generate new insights into disease mechanism, and develop innovative strategies for the accurate diagnosis and precise treatment of complex human diseases such as cancer.